Clinical Chemistry
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Clinical Chemistry 39: 667-669, 1993;
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Clinical Chemistry, Vol 39, 667-669, Copyright © 1993 by American Association for Clinical Chemistry

Respiratory chain enzyme activities in lymphocytes from untreated patients with Parkinson disease

N Barroso, Y Campos, R Huertas, J Esteban, JA Molina, A Alonso, E Gutierrez- Rivas and J Arenas
Servicio de Bioquimica, Hospital 12 de Octubre, Madrid, Spain.

Respiratory chain enzyme activities were studied in lymphocytes from patients with Parkinson disease (PD) (n = 16) and age-matched control subjects (n = 15). The patients had received no therapy before the study was conducted. Complex I, III, and IV activities were significantly lower (P < 0.05) in patients than in control subjects. A complex I defect was found in one patient, whereas complex IV was defective in another. Two patients had combined defects of both complexes. The use of lymphocytes for investigating the respiratory chain enzymes provides an easy, noninvasive method to assess mitochondrial function in patients with PD. Furthermore, our study supports the hypothesis that a biochemical defect in the respiratory chain may be involved in the pathogenesis of PD.


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Copyright © 1993 by the American Association for Clinical Chemistry.