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Clinical Chemistry, Vol 39, 683-686, Copyright © 1993 by American Association for Clinical Chemistry
MJ Hursting, AG Stead, FV Crout, BZ Horvath and BM Moore
Organon Teknika Corp., Durham, NC 27704.
Prothrombin fragment 1.2 (F1.2) is a biomarker of thrombin generation during blood coagulation and has diagnostic potential for assessing thrombotic risk and monitoring anticoagulation therapy. We used a monoclonal antibody-based immunoassay for plasma F1.2 to establish a well-defined reference interval and to evaluate the effects of age, race, sex, and smoking status on F1.2 concentrations in a healthy population. Plasma samples and demographic information were obtained from 357 healthy individuals. F1.2 concentrations more closely followed a lognormal than a gaussian frequency distribution. In a multiple linear-regression model in which the logarithms of F1.2 concentrations were regressed on age, race, sex, and smoking status, the significant explanatory variables were age and, to a lesser extent, sex and smoking. A segmented "hockey stick" regression model indicated that F1.2 concentrations and age were unrelated for individuals < 44 years old but were positively correlated above that age threshold. The estimated 95% tolerance interval (P = 0.95) for F1.2 in healthy individuals < 44 years old (n = 268) was 0.21-2.78 nmol/L. We conclude that age-matched F1.2 reference intervals may be important for studies evaluating the diagnostic utility of F1.2 measurements, and that the clinical relevance of increased thrombin generation during aging warrants further investigation.
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 S Kiraz, I Ertenli, M Benekli, I C Haznedarogul, M Calguneri, I Celik, S Apras, and S Kirazlil Clinical significance of hemostatic markers and thrombomodulin in systemic lupus erythematosus: evidence for a prothrombotic state Lupus, November 1, 1999; 8(9): 737 - 741. [Abstract] [PDF]
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W. M. Feinberg, E. S. Cornell, S. D. Nightingale, L. A. Pearce, R. P. Tracy, R. G. Hart, and E. G. Bovill Relationship Between Prothrombin Activation Fragment F1.2 and International Normalized Ratio in Patients With Atrial Fibrillation Stroke, June 1, 1997; 28(6): 1101 - 1106. [Abstract] [Full Text]
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 M. Cushman, B. M. Psaty, E. Macy, E. G. Bovill, E. S. Cornell, L. H. Kuller, and R. P. Tracy Correlates of Thrombin Markers in an Elderly Cohort Free of Clinical Cardiovascular Disease Arterioscler. Thromb. Vasc. Biol., September 1, 1996; 16(9): 1163 - 1169. [Abstract] [Full Text]
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