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Clinical Chemistry 39: 1050-1053, 1993;
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Clinical Chemistry, Vol 39, 1050-1053, Copyright © 1993 by American Association for Clinical Chemistry

Comparison of cyclosporin G (Nva2-cyclosporin) concentrations measured in whole blood by monoclonal fluorescence polarization immunoassay, monoclonal radioimmunoassay, and HPLC

TM Annesley, RC Coombs and PJ Orsulak
Department of Pathology, University of Michigan Medical Center, Ann Arbor 48109-0054.

Two commercial monoclonal immunoassays for monitoring cyclosporin A were used to measure whole-blood concentrations of the immunosuppressant cyclosporin G (CsG) in renal transplant patients. We performed a three-way comparison of these two immunoassays and HPLC. Although the two immunoassays agreed favorably, both the monoclonal fluorescence polarization immunoassay and the monoclonal RIA yielded higher CsG results for patients' specimens than did the liquid- chromatographic assay. The experimental data indicate that the observed differences are most likely due to the cross-reactivity of CsG metabolites in the immunoassays.




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Copyright © 1993 by the American Association for Clinical Chemistry.