Clinical Chemistry AACC Online Job Center
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 39: 1447-1453, 1993;
This Article
Right arrow Full Text (PDF)
Right arrow Submit an electronic Letter to
the Editor about this paper
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fraser, C. G.
Right arrow Articles by Petersen, P. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fraser, C. G.
Right arrow Articles by Petersen, P. H.

Clinical Chemistry, Vol 39, 1447-1453, Copyright © 1993 by American Association for Clinical Chemistry

Desirable standards for laboratory tests if they are to fulfill medical needs

CG Fraser and PH Petersen
Department of Biochemical Medicine, Ninewells Hospital and Medical School, Dundee, Scotland, UK.

Many strategies to define desirable standards for laboratory tests to fulfill medical needs have been proposed over the last three decades. Traditional approaches are based on reference (normal) values, opinions of clinicians, the state of the art, views of experts, data on biological variation, and assessment of the effect of error on clinical use. All these approaches have advantages and disadvantages, but the consensus of experts reached over a decade ago that imprecision desirably be less than one-half of the within-subject biological variation still seems to provide the best set of generally applicable performance standards. Desirable bias is less than one-quarter of the group (within-subject plus between-subject) biological variation. Recent proposals are either restatements of traditional recommendations, further empirical suggestions, or models based on assessment of clinical needs, and have not been widely accepted. Both old and new studies on clinical opinions, sought by using structured questionnaires containing clinical vignettes designed to seek views on the magnitude of significant change, are flawed in design, execution, and data analysis. Until clinicians are more aware of test-result variability and clinical chemists gain quantitative knowledge on the interpretation of test results, it will be difficult to set desirable standards that fulfill actual medical needs, except in a few well- defined screening situations.


The following articles in journals at HighWire Press have cited this article:


Home page
 Ann. N. Y. Acad. Sci.Home page
T. H. BRUMMENDORF, I. ERSOZ, U. HARTMANN, S. BALABANOV, H. WOLKE, P. PASCHKA, T. LAHAYE, B. BERNER, K. BARTOLOVIC, S. KREIL, et al.
Normalization of Previously Shortened Telomere Length under Treatment with Imatinib Argues against a Preexisting Telomere Length Deficit in Normal Hematopoietic Stem Cells from Patients with Chronic Myeloid Leukemia
Ann. N.Y. Acad. Sci., May 1, 2003; 996(1): 26 - 38.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
P. Meijer, M. P.M. de Maat, C. Kluft, F. Haverkate, and H. C. van Houwelingen
Long-Term Analytical Performance of Hemostasis Field Methods as Assessed by Evaluation of the Results of an External Quality Assessment Program for Antithrombin
Clin. Chem., July 1, 2002; 48(7): 1011 - 1015.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
C. M. Pfeiffer, S. J. Smith, D. T. Miller, and E. W. Gunter
Comparison of Serum and Plasma Methylmalonic Acid Measurements in 13 Laboratories: An International Study
Clin. Chem., December 1, 1999; 45(12): 2236 - 2242.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
C. M. Pfeiffer, D. L. Huff, S. J. Smith, D. T. Miller, and E. W. Gunter
Comparison of Plasma Total Homocysteine Measurements in 14 Laboratories: An International Study
Clin. Chem., August 1, 1999; 45(8): 1261 - 1268.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
K. Linnet
Necessary Sample Size for Method Comparison Studies Based on Regression Analysis
Clin. Chem., June 1, 1999; 45(6): 882 - 894.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
C. G. Fraser and P. Hyltoft Petersen
Analytical Performance Characteristics Should Be Judged against Objective Quality Specifications
Clin. Chem., March 1, 1999; 45(3): 321 - 323.
[Full Text] [PDF]

Home page
 Clin. Chem.Home page
M. Panteghini and F. Pagani
Evaluation of Two Automated Immunoassays for Measurement of Free Deoxypyridinoline in Urine Using Analytical Goals Derived from Biological Variation
Clin. Chem., December 1, 1998; 44(12): 2559 - 2559.
[Full Text] [PDF]

Home page
 Clin. Chem.Home page
S. C. Kazmierczak, P. G. Catrou, and D. Boudreau
Simplified interpretative format for assessing test interference: studies with hemoglobin-based oxygen carrier solutions
Clin. Chem., November 1, 1998; 44(11): 2347 - 2352.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
L. D. Bowers
Analytical goals in therapeutic drug monitoring
Clin. Chem., February 1, 1998; 44(2): 375 - 380.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
M. Stahl, I. Brandslund, S. Iversen, and J. A. Filtenborg
Quality assessment of blood glucose testing in general practitioners' offices improves quality
Clin. Chem., October 1, 1997; 43(10): 1926 - 1931.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
W. A. Sadler, M. H. Smith, L. M. Murray, and J. G. Turner
A pragmatic approach to estimating total analytical error of immunoassays
Clin. Chem., April 1, 1997; 43(4): 608 - 614.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1993 by the American Association for Clinical Chemistry.