Clinical Chemistry AACC Online Job Center
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 39: 1798-1803, 1993;
This Article
Right arrow Full Text (PDF)
Right arrow Submit an electronic Letter to
the Editor about this paper
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kicman, A. T.
Right arrow Articles by Cowan, D. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kicman, A. T.
Right arrow Articles by Cowan, D. A.

Clinical Chemistry, Vol 39, 1798-1803, Copyright © 1993 by American Association for Clinical Chemistry

Potential use of ketoconazole in a dynamic endocrine test to differentiate between biological outliers and testosterone use by athletes

AT Kicman, H Oftebro, C Walker, N Norman and DA Cowan
Drug Control and Teaching Centre, King's College London, UK.

Determination of the ratio of testosterone to epitestosterone (T/E) in urine is used to detect testosterone administration in athletes, with a ratio > 6 considered as evidence of an offense. We show that administration of ketoconazole, which inhibits testosterone biosynthesis, may be useful for differentiating between an athlete who is using testosterone and one who naturally gives a ratio > 6. In a control subject pretreated with testosterone, ketoconazole caused the ratio to increase; conversely, it caused a decrease in the ratio in an athlete under investigation. Repeated administration of ketoconazole to two normal men caused a decrease in the ratio due to a large decrease in the urinary excretion rate of testosterone relative to epitestosterone. Stimulation with human chorionic gonadotropin exacerbated the differences in excretion rates. A single administration of ketoconazole to six normal men caused the T/E ratios to decrease significantly within 8 h, a suitable time scale for use in a dynamic test.


The following articles in journals at HighWire Press have cited this article:


Home page
 J. Clin. Endocrinol. Metab.Home page
J. A. Schnorr, M. J. Bray, and J. D. Veldhuis
Aromatization Mediates Testosterone's Short-Term Feedback Restraint of 24-Hour Endogenously Driven and Acute Exogenous Gonadotropin-Releasing Hormone-Stimulated Luteinizing Hormone and Follicle-Stimulating Hormone Secretion in Young Men
J. Clin. Endocrinol. Metab., June 1, 2001; 86(6): 2600 - 2606.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
D. H. Catlin, C. K. Hatton, and S. H. Starcevic
Issues in detecting abuse of xenobiotic anabolic steroids and testosterone by analysis of athletes' urine
Clin. Chem., July 1, 1997; 43(7): 1280 - 1288.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
P. J. Perry, J. H. MacIndoe, W. R. Yates, S. D. Scott, and T. L. Holman
Detection of anabolic steroid administration: ratio of urinary testosterone to epitestosterone vs the ratio of urinary testosterone to luteinizing hormone
Clin. Chem., May 1, 1997; 43(5): 731 - 735.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1993 by the American Association for Clinical Chemistry.