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Clinical Chemistry 39: 1899-1903, 1993;
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Clinical Chemistry, Vol 39, 1899-1903, Copyright © 1993 by American Association for Clinical Chemistry

Multianalyte assay system developed for drugs of abuse [published erratum appears in Clin Chem 1993 Nov;39(11 Pt 1):2343]

RG Parsons, R Kowal, D LeBlond, VT Yue, L Neargarder, L Bond, D Garcia, D Slater and P Rogers
Diagnostics Division, Abbott Laboratories, North Chicago, IL 60064.

A simple, 10-min immunoassay system has been developed that simultaneously screens for five different classes of drugs of abuse in a urine sample. This system tests for amphetamines, cannabinoids, cocaine metabolites, opiates, and phencyclidine, and each assay has a specific preset cutoff concentration. Accuracy is > 99% for reporting positive or negative results for samples with 200% or 50%, respectively, of the cutoff concentrations of the drugs. Tests of a panel of 96 compounds yielded only three cases of nonspecific reactivity (at a drug concentration of 100 mg/L). Another panel of 12 compounds that could normally be found in urine samples was also evaluated and no interferences were observed. Concordance was > 95% between this system and the comparable automated immunoassays for detecting drugs of abuse. Greater than 98% of GC/MS-confirmed positive samples gave positive results with this assay system.




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Copyright © 1993 by the American Association for Clinical Chemistry.