Clinical Chemistry 4: 66-76, 1958;
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Clinical Chemistry, Vol 4, 66-76, Copyright © 1958 by the American Association for Clinical Chemistry

The Influence of Phenothiazine and Some of its Derivatives on the Determination of 5-Hydroxyincioleacetic Acid in Urine

George Ross 1, I. Bernard Weinstein 1, and Bernard Kabakow 1

1 Division of Laboratories and the Division of Neoplastic Diseases of Montefiore Hospital, New York, N. Y.

The experimental work in this paper demonstrates that derivatives of phenothiazine interfere with the chemical determination of 5-HIAA. This holds true when attempts are made to determine 5-HIAA in the presence of Compazine, Sparine, Phenergan or chlorpromazine, and in the case of the latter substance also when administered to a patient. Thus, it is impossible by the chemical method to determine 5-HIAA in the urine under these circumstances, and results so obtained will be incorrect. However, with the chromatographic method of Curzon (7) no such interference occurs, and, utilizing this technic, it is possible to determine 5-HIAA in the urine of a patient while he is receiving chlorpromazine. In this manner it was shown that the urinary excretion of 5-HIAA in a patient with metastatic carcinoid was not influenced by the administration of chlorpromazine. (See ADDENDUM, p. 76.)

Submitted on September 27, 1957




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