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Clinical Chemistry 4: 323-330, 1958;
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Clinical Chemistry, Vol 4, 323-330, Copyright © 1958 by the American Association for Clinical Chemistry

A Comparative Study of Qualitative Tests for Ketones in Urine and Serum

Helen M. Free 1, Robert R. Smeby 1, Marion H. Cook 1, and Alfred H. Free 1

1 Miles-Ames Research Laboratory, Elkhart, Ind.

Results are presented of a comparative study of several methods for detection of ketone bodies in urine involving nearly 10,000 tests on urines containing no ketones, naturally occurring ketones, and added acetoacetate. Acetest (a tablet nitroprusside test) and Ketostix (a strip nitroprusside test) are more specific and accurate, and have the proper sensitivity in comparison with test tube Rothera nitroprusside modifications or the ferric chloride test. Both the tablet and strip are also satisfactory for detection of ketones and serum or plasma. The tablet test may be used with whole blood for detection of ketonemia.

Submitted on March 20, 1958




The following articles in journals at HighWire Press have cited this article:


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ANN INTERN MEDHome page
W. S. Yancy Jr., M. K. Olsen, J. R. Guyton, R. P. Bakst, and E. C. Westman
A Low-Carbohydrate, Ketogenic Diet versus a Low-Fat Diet To Treat Obesity and Hyperlipidemia: A Randomized, Controlled Trial
Ann Intern Med, May 18, 2004; 140(10): 769 - 777.
[Abstract] [Full Text] [PDF]




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Copyright © 1958 by the American Association for Clinical Chemistry.