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Clinical Chemistry, Vol 40, 18-23, Copyright © 1994 by American Association for Clinical Chemistry
HA Schwertner, WG Jackson and G Tolan
USAF Medical Center/RDL, Lackland AFB, TX 78236-5319.
We examined serum bilirubin and various liver-function enzymes as possible risk factors for angiographically documented coronary artery disease (CAD). The studies involved a "training" set of 619 men for whom complete data on all risk factors considered were available, and a "test" set of 258 men for whom some risk factor data were not available. In both study groups, the liver enzymes were not related to CAD; however, In[total bilirubin] was inversely and statistically significantly related to the presence of CAD, both univariately and multivariately after adjustment for the established risk factors of age, total cholesterol, high-density lipoprotein cholesterol, smoking history, and systolic blood pressure. A 50% decrease in total bilirubin was associated with a 47% increase in the odds of being in a more severe CAD category. Our data suggest that serum bilirubin is an inverse and independent risk factor for CAD, with an association equivalent in degree to that of systolic blood pressure.
The following articles in journals at HighWire Press have cited this article:
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W. Durante, K. J. Peyton, and A. I. Schafer Platelet-Derived Growth Factor Stimulates Heme Oxygenase-1 Gene Expression and Carbon Monoxide Production in Vascular Smooth Muscle Cells Arterioscler Thromb Vasc Biol, November 1, 1999; 19(11): 2666 - 2672. [Abstract] [Full Text] [PDF]
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E. Beutler, T. Gelbart, and A. Demina Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promoter: A balanced polymorphism for regulation of bilirubin metabolism? PNAS, July 7, 1998; 95(14): 8170 - 8174. [Abstract] [Full Text] [PDF]
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R. P. Tracy Inflammation in Cardiovascular Disease : Cart, Horse, or Both? Circulation, May 26, 1998; 97(20): 2000 - 2002. [Full Text] [PDF]
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V. W. Bowry, D. Mohr, J. Cleary, and R. Stocker Prevention of Tocopherol-mediated Peroxidation in Ubiquinol-10-free Human Low Density Lipoprotein J. Biol. Chem., March 17, 1995; 270(11): 5756 - 5763. [Abstract] [Full Text] [PDF]
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