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Clinical Chemistry 40: 52-55, 1994;
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Clinical Chemistry, Vol 40, 52-55, Copyright © 1994 by American Association for Clinical Chemistry

Analytical evaluation of Kone Microlyte determination of ionized magnesium

HE van Ingen, HJ Huijgen, WT Kok and GT Sanders
Academic Medical Centre, Dept. of Clinical Chemistry, Amsterdam, The Netherlands.

We performed an analytical evaluation of a commercially available instrument for determining ionized magnesium through use of a neutral carrier, liquid-membrane-based ion-selective electrode. Reproducibility (CV 2-4%), linearity (0.30-2.50 mmol/L), lower limit of detection (0.30 mmol/L), and absence of interference from Ca2+ indicate adequate performance for measuring ionized magnesium in plasma or serum samples in the normal to high-concentration range. Sodium in excess of 150 mmol/L caused a negative bias, which can be explained by ionic strength- induced changes in activity coefficients. The use of heparin as an anticoagulant must be restricted to concentrations < 15 units/mL because of the binding of magnesium to heparin. The mean +/- SD concentration of ionized magnesium and its fraction of total magnesium in 76 healthy volunteers were 0.56 +/- 0.05 mmol/L and 0.65 +/- 0.04, respectively.


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