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Clinical Chemistry 40: 1921-1926, 1994;
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Clinical Chemistry, Vol 40, 1921-1926, Copyright © 1994 by American Association for Clinical Chemistry

Serum cystatin C, determined by a rapid, automated particle-enhanced turbidimetric method, is a better marker than serum creatinine for glomerular filtration rate

J Kyhse-Andersen, C Schmidt, G Nordin, B Andersson, P Nilsson-Ehle, V Lindstrom and A Grubb
Dako A/S, Glostrup, Denmark.

We describe a fully automated particle-enhanced turbidimetric assay for cystatin C in undiluted serum and EDTA-plasma. The throughput is 90 samples per hour and urgent samples can be analyzed in 7 min. The assay range (0.4-14.1 mg/L) covers the concentration range in health and disease. The within- and between-run imprecision is 0.9% and 2.2%, respectively. Analytical recovery of additions of recombinant cystatin C averaged 98%. Rheumatoid factors (< or = 323,000 IU/L), bilirubin (< or = 150 mumol/L), hemoglobin (< or = 1.2 g/L), and triglycerides (< or = 8.5 mmol/L) do not interfere in the assay. In view of the superior (by ROC analysis) diagnostic accuracy of serum concentrations of cystatin C for reduced glomerular filtration rate (GFR) in comparison with creatinine, cystatin C seems an attractive alternative to creatinine for estimation of GFR.


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Copyright © 1994 by the American Association for Clinical Chemistry.