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Clinical Chemistry 40: 1972-1974, 1994;
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Clinical Chemistry, Vol 40, 1972-1974, Copyright © 1994 by American Association for Clinical Chemistry

Association of pancreatic adenocarcinoma, mild lung disease, and delta F508 mutation in a cystic fibrosis patient

GJ Tsongalis, G Faber, FG Dalldorf, KJ Friedman, LM Silverman and JR Yankaskas
Department of Pathology, University of North Carolina School of Medicine, Chapel Hill 27514.

A case of adenocarcinoma of the pancreas and mild lung disease in a 39- year-old man homozygous for the delta F508 cystic fibrosis mutation is presented. Cystic fibrosis is the most common lethal genetic disease in Caucasians, and is most commonly associated with severe obstructive lung disease. To our knowledge, this is only the fifth case of adenocarcinoma of the pancreas in a CF patient to be reported and the first case for which molecular data are available. The rare incidence of this type of malignancy in the general population suggests a possible association of CF with this malignant disease.


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P Maisonneuve, B C Marshall, and A B Lowenfels
Risk of pancreatic cancer in patients with cystic fibrosis
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Cancer Risk in Nontransplanted and Transplanted Cystic Fibrosis Patients: A 10-Year Study
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