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Clinical Chemistry 40: 2276-2281, 1994;
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Clinical Chemistry, Vol 40, 2276-2281, Copyright © 1994 by American Association for Clinical Chemistry

Establishment of creatinine clearance reference values for older women

LJ Sokoll, RM Russell, JA Sadowski and FD Morrow
US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111.

Age-adjusted reference ranges for creatinine clearance were determined in 279 women, ages 40-95 years, who were housed in a metabolic research unit and consumed a meat-free diet. Creatinine clearance, but not serum creatinine, declined with age by 0.63 mL/min per 1.73 m2 per year. Serum and urine creatinine concentrations, used to calculate clearances, were analyzed by a kinetic Jaffe procedure. In a subset of 100 subjects, fasting serum creatinine values averaged 8.3 +/- 5.2 (SD) mumol/L higher when measured by the kinetic Jaffe procedure than by an enzymatic method (creatinine PAP). The Cockcroft-Gault formula for estimating creatinine clearance from serum creatinine in women was validated, and the modification factor for the male equation was determined to be 0.84 (95% confidence interval 0.83-0.86) confirming the suggested 15% correction. A prediction formula derived from this population was similar in accuracy to the Cockcroft-Gault formula.


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