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Clinical Chemistry, Vol 40, 227-232, Copyright © 1994 by American Association for Clinical Chemistry
GR Cooper, SJ Smith, GL Myers, EJ Sampson and E Magid
Centers for Disease Control and Prevention, National Center for Environmental Health, Atlanta, GA 30341-3724.
Biologic intraindividual variation (CVb) is a major source of inaccuracy in current lipid and lipoprotein measurements. Metaanalysis has been used to estimate the average CVb of serum total cholesterol (TC), high-density lipoprotein cholesterol (HDLC), low-density lipoprotein cholesterol (LDLC), and triglyceride (TG). These CVb values are larger than the National Cholesterol Education Program-accepted and -proposed analytic (CVa) goals. Measuring serial specimens reduces the error in determination of the mean concentration used in classification of the patient by cutoff points. We show (a) a convenient technique, based on the relative range, to qualitatively estimate and interpret biologic variation of TC, HDLC, LDLC, and TG, and (b) the number of serial specimens required to meet a total variation goal for measurements of mean lipid and lipoprotein values. A total variation goal has been selected that can be met by two serial specimens for a majority of individuals.
The following articles in journals at HighWire Press have cited this article:
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  G. R. Warnick and K. Nakajima Fasting versus Nonfasting Triglycerides: Implications for Laboratory Measurements Clin. Chem., January 1, 2008; 54(1): 14 - 16. [Full Text] [PDF]
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 I. S. Young Lipids for Psychiatrists - an overview J Psychopharmacol, November 1, 2005; 19(6_suppl): 66 - 75. [Abstract] [PDF]
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 C. Gillespie, C. Ballew, B. A Bowman, R. Donehoo, and M. K Serdula Intraindividual variation in serum retinol concentrations among participants in the third National Health and Nutrition Examination Survey, 1988-1994 Am. J. Clinical Nutrition, April 1, 2004; 79(4): 625 - 632. [Abstract] [Full Text] [PDF]
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J. Middleton Effect of Analytical Error on the Assessment of Cardiac Risk by the High-Sensitivity C-Reactive Protein and Lipid Screening Model Clin. Chem., November 1, 2002; 48(11): 1955 - 1962. [Abstract] [Full Text] [PDF]
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H. W. Vesper, L. M. Demers, R. Eastell, P. Garnero, M. Kleerekoper, S. P. Robins, A. K. Srivastava, G. R. Warnick, N. B. Watts, and G. L. Myers Assessment and Recommendations on Factors Contributing to Preanalytical Variability of Urinary Pyridinoline and Deoxypyridinoline Clin. Chem., February 1, 2002; 48(2): 220 - 235. [Abstract] [Full Text] [PDF]
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S. P. Caudill, G. R. Cooper, S. J. Smith, and G. L. Myers Assessment of current National Cholesterol Education Program guidelines for total cholesterol, triglyceride, HDL-cholesterol, and LDL-cholesterol measurements Clin. Chem., August 1, 1998; 44(8): 1650 - 1658. [Abstract] [Full Text] [PDF]
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S. P. Caudill, S. J. Smith, G. R. Cooper, G. L. Myers, J. O. Westgard, and D. A. Wiebe Adequacy of NCEP Recommendations for Total Cholesterol, Triglycerides, HDLC, and LDLC Measurements Two of the authors of the above- mentioned article reply: Clin. Chem., May 1, 1998; 44(5): 1063 - 1066. [Full Text] [PDF]
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 P. W.F. Wilson, J. M. Hoeg, R. B. D'Agostino, H. Silbershatz, A. M. Belanger, H. Poehlmann, D. O'Leary, and P. A. Wolf Cumulative Effects of High Cholesterol Levels, High Blood Pressure, and Cigarette Smoking on Carotid Stenosis N. Engl. J. Med., August 21, 1997; 337(8): 516 - 522. [Abstract] [Full Text] [PDF]
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 A. Cohen, R. Beck, and G. R. Cooper In Reply.-- JAMA, August 13, 1997; 278(6): 478 - 478. [Abstract] [PDF]
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 P. W. F. Wilson Cholesterol Screening: Once Is Not Enough Arch Intern Med, November 13, 1995; 155(20): 2146 - 2147. [Abstract] [PDF]
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