Clinical Chemistry
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Clinical Chemistry 40: 260-264, 1994;
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Clinical Chemistry, Vol 40, 260-264, Copyright © 1994 by American Association for Clinical Chemistry

Quantification of serum 1,5-anhydroglucitol in uremic and diabetic patients by liquid chromatography/mass spectrometry

T Niwa, L Dewald, J Sone, T Miyazaki and M Kajita
Nagoya University Branch Hospital, Japan.

We developed a new method for measuring serum 1,5-anhydroglucitol (1,5- AG), using liquid chromatography/atmospheric pressure chemical- ionization mass spectrometry (LC/MS). With this method we measured serum 1,5-AG concentrations in uremic and diabetic patients and compared these values with those determined by an enzymatic method. Serum 1,5-AG concentrations were significantly less in the undialyzed and dialyzed uremic patients and in diabetic patients; the values in the dialyzed patients decreased after hemodialysis. In uremic patients with high concentrations of serum myo-inositol, the 1,5-AG values determined by LC/MS were significantly lower than those determined enzymatically. There was no significant correlation between 1,5-AG and fructosamine in the uremic patients. These results demonstrate that serum 1,5-AG cannot be used as an index for glycemic control in uremic patients and that the LC/MS method is indicated in uremic patients with high concentrations of myo-inositol.


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 Am. J. Physiol. Endocrinol. Metab.Home page
D. Stickle and J. Turk
A kinetic mass balance model for 1,5-anhydroglucitol: applications to monitoring of glycemic control
Am J Physiol Endocrinol Metab, October 1, 1997; 273(4): E821 - E830.
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Copyright © 1994 by the American Association for Clinical Chemistry.