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Clinical Chemistry 40: 364-368, 1994;
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Clinical Chemistry, Vol 40, 364-368, Copyright © 1994 by American Association for Clinical Chemistry

Two methods for measuring carbohydrate-deficient transferrin in inpatient alcoholics and healthy controls compared

R Anton and P Bean
Medical University of South Carolina, Charleston 29425-0742.

Carbohydrate-deficient transferrins (CDTs), naturally occurring glycosylated transferrin proteins, are reported to be increased in the serum of individuals who consume large quantities of alcohol (ethanol). We compared two methods for the separation and quantification of CDT, using the same alcohol-dependent patients and age-, gender-, and race- matched controls as sources of samples for both assays. There was good correlation (r = 0.89) between the microcolumn anion-exchange chromatography/RIA (MAEC/RIA) procedure and the isoelectric focusing, immunoblotting, and laser densitometry (IEF/IB/LD) procedure. Receiver operating characteristic analysis suggested that the IEF/IB/LD procedure would perform slightly better than MAEC/RIA for the overall population. However, both assays were much more sensitive for the detection of heavy alcohol consumption in men, compared with women. Alcohol consumption in the week prior to CDT measurement correlated only weakly with the concentrations measured with either assay.


The following articles in journals at HighWire Press have cited this article:


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R. F. Anton, C. Dominick, M. Bigelow, and C. Westby
Comparison of Bio-Rad %CDT TIA and CDTect as Laboratory Markers of Heavy Alcohol Use and Their Relationships with {gamma}-Glutamyltransferase
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A. Helander
Absolute or Relative Measurement of Carbohydrate-deficient Transferrin in Serum? Experiences with Three Immunological Assays
Clin. Chem., January 1, 1999; 45(1): 131 - 135.
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A. Helander, E. Vabo, K. Levin, and S. Borg
Intra- and interindividual variability of carbohydrate-deficient transferrin, {gamma}-glutamyltransferase, and mean corpuscular volume in teetotalers
Clin. Chem., October 1, 1998; 44(10): 2120 - 2125.
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K. Viitala, K. Lahdesmaki, and O. Niemela
Comparison of the Axis %CDT TIA and the CDTect method as laboratory tests of alcohol abuse
Clin. Chem., June 1, 1998; 44(6): 1209 - 1215.
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P. Bean, K. Liegmann, T. Lovli, C. Westby, and E. Sundrehagen
Semiautomated procedures for evaluation of carbohydrate-deficient transferrin in the diagnosis of alcohol abuse
Clin. Chem., June 1, 1997; 43(6): 983 - 989.
[Abstract] [Full Text] [PDF]

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F. Renner and R.-D. Kanitz
Quantification of carbohydrate-deficient transferrin by ion-exchange chromatography with an enzymatically prepared calibrator
Clin. Chem., March 1, 1997; 43(3): 485 - 490.
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Copyright © 1994 by the American Association for Clinical Chemistry.