| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Clinical Chemistry, Vol 40, 478-483, Copyright © 1994 by American Association for Clinical Chemistry
G Castaldo, G Oriani, L Cimino, M Topa, I Mostarda, L Castellano, C Del Vecchio- Blanco, G Budillon, F Salvatore and L Sacchetti
Dipartimento di Biochimica e Biotecnologie Mediche, Facolta di Medicina, Universita di Napoli Federico II, Naples, Italy.
No laboratory test completely distinguishes malignant ascites (MA) from ascites associated with cirrhosis and (or) hepatocellular carcinoma (A/C-HC). Ascitic cytology is highly specific but has a diagnostic sensitivity of only 40-60%. We determined 11 ascitic analytes and cytology in 58 patients with cirrhosis, 15 with hepatocellular carcinoma, and 21 with MA (10 ovarian cancers, 4 mesotheliomas, 6 gastrointestinal neoplasias, 1 leukemia). Ascitic total protein, cholesterol, pseudouridine, and lactate dehydrogenase (LD), and the ascitic:serum ratios of total protein and of LD showed the most significant differences between the two groups of patients. Stepwise multiple linear discriminant analysis (applying the Wilks' lambda criterion) of several variables, corroborated by the "jack-knife" reallocation procedure, showed that the ascitic cholesterol and ascitic LD association correctly identified 100% of MA and A/C-HC; cytology had a diagnostic specificity of 100%, but identified only 48% of MA. This association may represent a primary tool for the discrimination of ascites of unknown origin, particularly in the presence of negative cytology findings.
The following articles in journals at HighWire Press have cited this article:
|
|
 |
|
  D. D. Nestor, S. M. McCullough, and D. J. Schaeffer Biochemical Analysis of Neoplastic Versus Nonneoplastic Abdominal Effusions in Dogs J. Am. Anim. Hosp. Assoc., September 1, 2004; 40(5): 372 - 375. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R O S Karoo, T D R Lloyd, G Garcea, H D Redway, and G S R Robertson How valuable is ascitic cytology in the detection and management of malignancy? Postgrad. Med. J., May 1, 2003; 79(931): 292 - 294. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M Gulyas, A D Kaposi, G Elek, L G Szollar, and A Hjerpe Value of carcinoembryonic antigen (CEA) and cholesterol assays of ascitic fluid in cases of inconclusive cytology J. Clin. Pathol., November 1, 2001; 54(11): 831 - 835. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Fortunato, G. Castaldo, G. Oriani, R. Cerini, M. Intrieri, E. Molinaro, I. Gentile, G. Borgia, M. Piazza, F. Salvatore, et al. Multivariate Discriminant Function Based on Six Biochemical Markers in Blood Can Predict the Cirrhotic Evolution of Chronic Hepatitis Clin. Chem., September 1, 2001; 47(9): 1696 - 1700. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Tangkijvanich, D. Tresukosol, P. Sampatanukul, S. Sakdikul, N. Voravud, V. Mahachai, and A. Mutirangura Telomerase Assay for Differentiating between Malignancy-related and Nonmalignant Ascites Clin. Cancer Res., September 1, 1999; 5(9): 2470 - 2475. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Mannello, G. Miragoli, G. Bianchi, and G. Gazzanelli Prostate-Specific Antigen in Ascitic Fluid Clin. Chem., August 1, 1997; 43(8): 1461 - 1462. [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
