Clinical Chemistry
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 40: 552-561, 1994;
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wu, L. L.
Right arrow Articles by Hopkins, P. N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wu, L. L.
Right arrow Articles by Hopkins, P. N.

Clinical Chemistry, Vol 40, 552-561, Copyright © 1994 by American Association for Clinical Chemistry

Plasma homocyst(e)ine as a risk factor for early familial coronary artery disease

LL Wu, J Wu, SC Hunt, BC James, GM Vincent, RR Williams and PN Hopkins
Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City 84132.

We measured plasma homocyst(e)ine [H(e)] and other coronary risk factors in 266 patients with early coronary artery disease from 170 families in which two or more siblings were affected and in 168 unmatched controls. The mean H(e) concentration adjusted for significant correlates (serum creatinine, uric acid, and low-density lipoprotein cholesterol) was 12.0 mumol/L in proband cases compared with 10.1 mumol/L in controls (P = 0.0001). Many (17.6%) of the proband cases had H(e) concentrations exceeding the 95th percentile for the controls (relative odds = 4.9, P < 0.001). H(e) among cases was bimodally distributed even after adjustment for concentrations of plasma vitamins. Concordant high H(e) was seen in at least 10 (12%) of 85 families with two or more affected siblings. We conclude that a substantial proportion of early familial coronary artery disease is probably related to production of high concentrations of H(e) by one or more major genes.


The following articles in journals at HighWire Press have cited this article:


Home page
 Occup. Environ. Med.Home page
S. E. Chia, S. M. Ali, B. L. Lee, G. H. Lim, S. Jin, N.-V. Dong, N. T. H. Tu, C. N. Ong, and K. S. Chia
Association of blood lead and homocysteine levels among lead exposed subjects in Vietnam and Singapore
Occup. Environ. Med., October 1, 2007; 64(10): 688 - 693.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
D. Vanuzzo, L. Pilotto, R. Lombardi, G. Lazzerini, M. Carluccio, S. Diviacco, F. Quadrifoglio, G. Danek, D. Gregori, P. Fioretti, et al.
Both vitamin B6 and total homocysteine plasma levels predict long-term atherothrombotic events in healthy subjects
Eur. Heart J., February 2, 2007; 28(4): 484 - 491.
[Abstract] [Full Text] [PDF]

Home page
 Annals of Clinical & Laboratory ScienceHome page
E.-C. Chan, P.-Y. Chang, T.-L. Wu, and J. T. Wu
Enzymatic Assay of Homocysteine on Microtiter Plates or a TECAN Analyzer Using Crude Lysate Containing Recombinant Methionine {gamma}-Lyase
Ann. Clin. Lab. Sci., April 1, 2005; 35(2): 155 - 160.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
R. G. V. Smolders, K. de Meer, P. Kenemans, C. Jakobs, W. Kulik, and M. J. van der Mooren
Oral Estradiol Decreases Plasma Homocysteine, Vitamin B6, and Albumin in Postmenopausal Women But Does Not Change the Whole-Body Homocysteine Remethylation and Transmethylation Flux
J. Clin. Endocrinol. Metab., April 1, 2005; 90(4): 2218 - 2224.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
R. Rej
Clinical Chemistry through Clinical Chemistry: A Journal Timeline
Clin. Chem., December 1, 2004; 50(12): 2415 - 2458.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
M. Klerk, P. Verhoef, R. Clarke, H. J. Blom, F. J. Kok, E. G. Schouten, and and the MTHFR Studies Collaboration Group
MTHFR 677C->T Polymorphism and Risk of Coronary Heart Disease: A Meta-analysis
JAMA, October 23, 2002; 288(16): 2023 - 2031.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
P. O'Callaghan, R. Meleady, T. Fitzgerald, I. Graham, and European COMAC group
Smoking and plasma homocysteine
Eur. Heart J., October 2, 2002; 23(20): 1580 - 1586.
[Abstract] [Full Text] [PDF]

Home page
 Int J EpidemiolHome page
E. S Ford, S J. Smith, D. F Stroup, K. K Steinberg, P. W Mueller, and S. B Thacker
Homocyst(e)ine and cardiovascular disease: a systematic review of the evidence with special emphasis on case-control studies and nested case-control studies
Int. J. Epidemiol., February 1, 2002; 31(1): 59 - 70.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
N. Matsuyama, M. Yamaguchi, M. Toyosato, M. Takayama, and K. Mizuno
New Enzymatic Colorimetric Assay for Total Homocysteine
Clin. Chem., December 1, 2001; 47(12): 2155 - 2156.
[Full Text] [PDF]

Home page
 JAMAHome page
J. A. Tice, E. Ross, P. G. Coxson, I. Rosenberg, M. C. Weinstein, M. G. M. Hunink, P. A. Goldman, L. Williams, and L. Goldman
Cost-effectiveness of Vitamin Therapy to Lower Plasma Homocysteine Levels for the Prevention of Coronary Heart Disease: Effect of Grain Fortification and Beyond
JAMA, August 22, 2001; 286(8): 936 - 943.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
G. Liaugaudas, P. F. Jacques, J. Selhub, I. H. Rosenberg, and A. G. Bostom
Renal Insufficiency, Vitamin B12 Status, and Population Attributable Risk for Mild Hyperhomocysteinemia Among Coronary Artery Disease Patients in the Era of Folic Acid-Fortified Cereal Grain Flour
Arterioscler Thromb Vasc Biol, May 1, 2001; 21(5): 849 - 851.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
C. M. Tribouilloy, M. Peltier, M. C. Iannetta Peltier, F. Trojette, M. Andrejak, and J.-P. M. Lesbre
Plasma Homocysteine and Severity of Thoracic Aortic Atherosclerosis
Chest, December 1, 2000; 118(6): 1685 - 1689.
[Abstract] [Full Text] [PDF]

Home page
 CMAJHome page
G. L. Booth, E. E.L. Wang, and with the Canadian Task Force on Preventive Health
Preventive health care, 2000 update: screening and management of hyperhomocysteinemia for the prevention of coronary artery disease events
Can. Med. Assoc. J., July 1, 2000; 163(1): 21 - 29.
[Abstract] [Full Text] [PDF]

Home page
 ANGIOLOGYHome page
V. Richter, C. Janke, K. Purschwitz, B. Klotzer, J. Geisel, W. Herrmann, and F. Rassoul
Plasma Homocysteine and Lipoprotein Profile in Patients with Peripheral Arterial Occlusive Disease
Angiology, March 1, 2000; 51(3): 189 - 196.
[Abstract] [PDF]

Home page
 Arch Intern MedHome page
W. G. Christen, U. A. Ajani, R. J. Glynn, and C. H. Hennekens
Blood Levels of Homocysteine and Increased Risks of Cardiovascular Disease: Causal or Casual?
Arch Intern Med, February 28, 2000; 160(4): 422 - 434.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
K. Gempel, K.-D. Gerbitz, B. Casetta, and M. F. Bauer
Rapid Determination of Total Homocysteine in Blood Spots by Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry,
Clin. Chem., January 1, 2000; 46(1): 122 - 123.
[Full Text] [PDF]

Home page
 Clin. Chem.Home page
K. Rasmussen, J. Moller, and M. Lyngbak
Within-Person Variation of Plasma Homocysteine and Effects of Posture and Tourniquet Application
Clin. Chem., October 1, 1999; 45(10): 1850 - 1855.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
A. G. Bostom, L. Bausserman, P. F. Jacques, G. Liaugaudas, J. Selhub, and I. H. Rosenberg
Cystatin C as a Determinant of Fasting Plasma Total Homocysteine Levels in Coronary Artery Disease Patients With Normal Serum Creatinine
Arterioscler Thromb Vasc Biol, September 1, 1999; 19(9): 2241 - 2244.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
S. C. de Jong, C. D. A. Stehouwer, M. van den Berg, P. J. Kostense, D. Alders, C. Jakobs, G. Pals, and J. A. Rauwerda
Determinants of Fasting and Post-Methionine Homocysteine Levels in Families Predisposed to Hyperhomocysteinemia and Premature Vascular Disease
Arterioscler Thromb Vasc Biol, May 1, 1999; 19(5): 1316 - 1324.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
A. G. BOSTOM and B. F. CULLETON
Hyperhomocysteinemia in Chronic Renal Disease
J. Am. Soc. Nephrol., April 1, 1999; 10(4): 891 - 900.
[Full Text]

Home page
 StrokeHome page
W. H. Giles, J. B. Croft, K. J. Greenlund, E. S. Ford, and S. J. Kittner
Total Homocyst(e)ine Concentration and the Likelihood of Nonfatal Stroke : Results From the Third National Health and Nutrition Examination Survey, 1988–1994
Stroke, December 1, 1998; 29(12): 2473 - 2477.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
H. Morita, H. Kurihara, S.-i. Tsubaki, T. Sugiyama, C. Hamada, Y. Kurihara, T. Shindo, Y. Oh-hashi, K. Kitamura, and Y. Yazaki
Methylenetetrahydrofolate Reductase Gene Polymorphism and Ischemic Stroke in Japanese
Arterioscler Thromb Vasc Biol, September 1, 1998; 18(9): 1465 - 1469.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
D. W. Jacobsen
Homocysteine and vitamins in cardiovascular disease
Clin. Chem., August 1, 1998; 44(8): 1833 - 1843.
[Abstract] [Full Text] [PDF]

Home page
 Arch Intern MedHome page
J. H. Stein and P. E. McBride
Hyperhomocysteinemia and Atherosclerotic Vascular Disease: Pathophysiology, Screening, and Treatment
Arch Intern Med, June 22, 1998; 158(12): 1301 - 1306.
[Abstract] [Full Text] [PDF]

Home page
 Arch Intern MedHome page
N. J. Wald, H. C. Watt, M. R. Law, D. G. Weir, J. McPartlin, and J. M. Scott
Homocysteine and Ischemic Heart Disease: Results of a Prospective Study With Implications Regarding Prevention
Arch Intern Med, April 27, 1998; 158(8): 862 - 867.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
K. Robinson, K. Arheart, H. Refsum, L. Brattstrom, G. Boers, P. Ueland, P. Rubba, R. Palma-Reis, R. Meleady, L. Daly, et al.
Low Circulating Folate and Vitamin B6 Concentrations : Risk Factors for Stroke, Peripheral Vascular Disease, and Coronary Artery Disease
Circulation, February 10, 1998; 97(5): 437 - 443.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
E. J. Giltay, E. K. Hoogeveen, J. M. H. Elbers, L. J. G. Gooren, H. Asscheman, and C. D. A. Stehouwer
Effects of Sex Steroids on Plasma Total Homocysteine Levels: A Study in Transsexual Males and Females
J. Clin. Endocrinol. Metab., February 1, 1998; 83(2): 550 - 553.
[Abstract] [Full Text]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
S. C. de Jong, C. D. A. Stehouwer, A. J. C. Mackaay, M. van den Berg, E. J. Bulterijs, F. C. Visser, J. Bax, and J. A. Rauwerda
High Prevalence of Hyperhomocysteinemia and Asymptomatic Vascular Disease in Siblings of Young Patients With Vascular Disease and Hyperhomocysteinemia
Arterioscler Thromb Vasc Biol, November 1, 1997; 17(11): 2655 - 2662.
[Abstract] [Full Text]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
P. N. Hopkins, L. L. Wu, S. C. Hunt, B. C. James, G. M. Vincent, and R. R. Williams
Lipoprotein(a) Interactions With Lipid and Nonlipid Risk Factors in Early Familial Coronary Artery Disease
Arterioscler Thromb Vasc Biol, November 1, 1997; 17(11): 2783 - 2792.
[Abstract] [Full Text]

Home page
 CLIN APPL THROMB HEMOSTHome page
K. Kottke-Marchant, R. Green, D. W. Jacobsen, A. Gupta, S. R. Savon, M. Secic, and K. Robinson
High Plasma Homocysteine: A Risk Factor for Arterial and Venous Thrombosis in Patients with Normal Coagulation Profiles
Clinical and Applied Thrombosis/Hemostasis, October 1, 1997; 3(4): 239 - 244.
[Abstract] [PDF]

Home page
 CirculationHome page
S. M. Schwartz, D. S. Siscovick, M. R. Malinow, F. R. Rosendaal, R. K. Beverly, D. L. Hess, B. M. Psaty, W. T. Longstreth Jr, T. D. Koepsell, T. E. Raghunathan, et al.
Myocardial Infarction in Young Women in Relation to Plasma Total Homocysteine, Folate, and a Common Variant in the Methylenetetrahydrofolate Reductase Gene
Circulation, July 15, 1997; 96(2): 412 - 417.
[Abstract] [Full Text]

Home page
 CirculationHome page
H. Morita, J.-i. Taguchi, H. Kurihara, M. Kitaoka, H. Kaneda, Y. Kurihara, K. Maemura, T. Minamino, M. Ohno, K. Yamaoki, et al.
Genetic Polymorphism of 5,10-Methylenetetrahydrofolate Reductase (MTHFR) as a Risk Factor for Coronary Artery Disease
Circulation, April 15, 1997; 95(8): 2032 - 2036.
[Abstract] [Full Text]

Home page
 CirculationHome page
A. Tawakol, T. Omland, M. Gerhard, J. T. Wu, and M. A. Creager
Hyperhomocyst(e)inemia Is Associated With Impaired Endothelium-Dependent Vasodilation in Humans
Circulation, March 4, 1997; 95(5): 1119 - 1121.
[Abstract] [Full Text]

Home page
 BMJHome page
I. Graham and R. Meleady
Heart attacks and homocysteine
BMJ, December 7, 1996; 313(7070): 1419 - 1420.
[Full Text]

Home page
 CirculationHome page
J. Ma, M. J. Stampfer, C. H. Hennekens, P. Frosst, J. Selhub, J. Horsford, M. R. Malinow, W. C. Willett, and R. Rozen
Methylenetetrahydrofolate Reductase Polymorphism, Plasma Folate, Homocysteine, and Risk of Myocardial Infarction in US Physicians
Circulation, November 15, 1996; 94(10): 2410 - 2416.
[Abstract] [Full Text]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
P. N. Hopkins, L. L. Wu, S. C. Hunt, B. C. James, G. M. Vincent, and R. R. Williams
Higher Serum Bilirubin Is Associated With Decreased Risk for Early Familial Coronary Artery Disease
Arterioscler Thromb Vasc Biol, February 1, 1996; 16(2): 250 - 255.
[Abstract] [Full Text]

Home page
 JAMAHome page
O. Nygard, S. E. Vollset, H. Refsum, I. Stensvold, A. Tverdal, J. E. Nordrehaug, P. M. Ueland, and G. Kvale
Total Plasma Homocysteine and Cardiovascular Risk Profile: The Hordaland Homocysteine Study
JAMA, November 15, 1995; 274(19): 1526 - 1533.
[Abstract] [PDF]

Home page
 CirculationHome page
K. Robinson, E. L. Mayer, D. P. Miller, R. Green, F. van Lente, A. Gupta, K. Kottke-Marchant, S. R. Savon, J. Selhub, S. E. Nissen, et al.
Hyperhomocysteinemia and Low Pyridoxal Phosphate : Common and Independent Reversible Risk Factors for Coronary Artery Disease
Circulation, November 15, 1995; 92(10): 2825 - 2830.
[Abstract] [Full Text]

Home page
 JAMAHome page
C. J. Boushey, S. A. A. Beresford, G. S. Omenn, and A. G. Motulsky
A Quantitative Assessment of Plasma Homocysteine as a Risk Factor for Vascular Disease: Probable Benefits of Increasing Folic Acid Intakes
JAMA, October 4, 1995; 274(13): 1049 - 1057.
[Abstract] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
P. N. Hopkins, L. L. Wu, J. Wu, S. C. Hunt, B. C. James, G. M. Vincent, and R. R. Williams
Higher Plasma Homocyst(e)ine and Increased Susceptibility to Adverse Effects of Low Folate in Early Familial Coronary Artery Disease
Arterioscler Thromb Vasc Biol, September 1, 1995; 15(9): 1314 - 1320.
[Abstract] [Full Text]

Home page
 StrokeHome page
A. Lindgren, L. Brattstrom, B. Norrving, B. Hultberg, A. Andersson, and B. B. Johansson
Plasma Homocysteine in the Acute and Convalescent Phases After Stroke
Stroke, May 1, 1995; 26(5): 795 - 800.
[Abstract] [Full Text]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
M. A. Mansoor, C. Bergmark, A. M. Svardal, P. E. Lonning, and P. M. Ueland
Redox Status and Protein Binding of Plasma Homocysteine and Other Aminothiols in Patients With Early-Onset Peripheral Vascular Disease : Homocysteine and Peripheral Vascular Disease
Arterioscler Thromb Vasc Biol, February 1, 1995; 15(2): 232 - 240.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1994 by the American Association for Clinical Chemistry.