| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Clinical Chemistry, Vol 40, 574-578, Copyright © 1994 by American Association for Clinical Chemistry
SM Marcovina, VP Gaur and JJ Albers
Department of Medicine, Northwest Lipid Research Laboratories, University of Washington, Seattle 98103.
Biological variability is a major contributor to the inaccuracy of cardiovascular risk assessments based on measurement of lipids, lipoproteins, or apolipoproteins. We obtained estimates of biological variation (CVb) for 20 healthy adults and calculated the percentiles of CVb as an expression of the variability of CVb among individuals for cholesterol, triglyceride, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, apolipoprotein (apo) A-I, apo B, and lipoprotein(a) [Lp(a)] by four biweekly measurements of these analytes. The CVb for the group was approximately 6-7% for cholesterol, HDL cholesterol, apo A-I, and apo B; approximately 9% for LDL cholesterol; and 28% for triglyceride. However, for each analyte, there was a considerable variation of CVb among individuals. For all analytes except Lp(a), there was no relation between the individual's CVb and the analyte concentration. Lp(a) was inversely related to CVb, and there was a very wide variation in the CVb for Lp(a) among the participants, ranging from 1% to 51%. The number of independent analyses to perform to accurately assess an individual's risk for coronary artery disease should be determined on the basis of the individual CVb for a given analyte rather than the average CVb.
The following articles in journals at HighWire Press have cited this article:
|
|
 |
|
  R. McPherson A Gene-Centric Approach to Elucidating Cardiovascular Risk Circ Cardiovasc Genet, February 1, 2009; 2(1): 3 - 6. [Full Text] [PDF]
|
|
|
|
 |
|
 F. Magkos, B. W. Patterson, and B. Mittendorfer Reproducibility of stable isotope-labeled tracer measures of VLDL-triglyceride and VLDL-apolipoprotein B-100 kinetics J. Lipid Res., May 1, 2007; 48(5): 1204 - 1211. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. G Barnett, J. C van der Pols, and A. J Dobson Regression to the mean: what it is and how to deal with it Int. J. Epidemiol., February 1, 2005; 34(1): 215 - 220. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Bornhorst, R. F. Roberts, and W. L. Roberts Assay-Specific Differences in Lipemic Interference in Native and Intralipid-Supplemented Samples Clin. Chem., November 1, 2004; 50(11): 2197 - 2201. [Full Text] [PDF]
|
|
|
|
 |
|
 T. Marshall and A. Rouse Resource implications and health benefits of primary prevention strategies for cardiovascular disease in people aged 30 to 74: mathematical modelling study BMJ, July 27, 2002; 325(7357): 197 - 197. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. B. Dent, C. T. Peterson, L. D. Brace, J. H. Swain, M. B. Reddy, K. B. Hanson, J. G. Robinson, and D. L. Alekel Soy Protein Intake by Perimenopausal Women Does Not Affect Circulating Lipids and Lipoproteins or Coagulation and Fibrinolytic Factors J. Nutr., September 1, 2001; 131(9): 2280 - 2287. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. J. Shih, P. S. Bachorik, J. A. Haga, G. L. Myers, and E. A. Stein Estimating the Long-Term Effects of Storage at -70 {degrees}C on Cholesterol, Triglyceride, and HDL-Cholesterol Measurements in Stored Sera Clin. Chem., March 1, 2000; 46(3): 351 - 364. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Gotto Jr, E. Whitney, E. A. Stein, D. R. Shapiro, M. Clearfield, S. Weis, J. Y. Jou, A. Langendorfer, P. A. Beere, D. J. Watson, et al. Relation Between Baseline and On-Treatment Lipid Parameters and First Acute Major Coronary Events in the Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS) Circulation, February 8, 2000; 101(5): 477 - 484. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Marcovina, H. Kennedy, G. B. Bon, G. Cazzolato, C. Galli, E. Casiglia, M. Puato, and P. Pauletto Fish Intake, Independent of Apo(a) Size, Accounts for Lower Plasma Lipoprotein(a) Levels in Bantu Fishermen of Tanzania : The Lugalawa Study Arterioscler Thromb Vasc Biol, May 1, 1999; 19(5): 1250 - 1256. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Jungner, S. M. Marcovina, G. Walldius, I. Holme, W. Kolar, and E. Steiner Apolipoprotein B and A-I values in 147 576 Swedish males and females, standardized according to the World Health Organization–International Federation of Clinical Chemistry First International Reference Materials Clin. Chem., August 1, 1998; 44(8): 1641 - 1649. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. F. Asztalos, M. Lefevre, T. A. Foster, R. Tulley, M. Windhauser, L. Wong, and P. S. Roheim Normolipidemic Subjects With Low HDL Cholesterol Levels Have Altered HDL Subpopulations Arterioscler Thromb Vasc Biol, October 1, 1997; 17(10): 1885 - 1893. [Abstract] [Full Text]
|
|
|
|
|
|
C. Cobbaert, J. C. Arentsen, P. Mulder, N. Hoogerbrugge, and J. Lindemans Significance of various parameters derived from biological variability of lipoprotein(a), homocysteine, cysteine, and total antioxidant status Clin. Chem., October 1, 1997; 43(10): 1958 - 1964. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. H. Wild, S. P. Fortmann, and S. M. Marcovina A Prospective Case-Control Study of Lipoprotein(a) Levels and Apo(a) Size and Risk of Coronary Heart Disease in Stanford Five-City Project Participants Arterioscler Thromb Vasc Biol, February 1, 1997; 17(2): 239 - 245. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
