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Clinical Chemistry, Vol 40, 774-776, Copyright © 1994 by American Association for Clinical Chemistry
K Punnonen, K Irjala and A Rajamaki
Department of Clinical Chemistry, University Central Hospital of Turku, Finland.
We evaluated the use of transferrin receptor (TfR) in serum as an index of iron deficiency in 19 patients diagnosed as having iron-deficiency anemia, in 17 patients with anemia of chronic disease, and in a control group of 19 nonanemic patients who underwent elective ocular or nasopharyngeal surgery. The assessment of iron status of the anemic patients was based on the presence of stainable iron on bone marrow examination. In the patients with iron-deficiency anemia, the serum TfR concentration was 5.3 +/- 1.8 mg/L (mean +/- SD), significantly higher than in the control group (1.7 +/- 0.5 mg/L) or in the patients with anemia of chronic disease (1.6 +/- 0.4 mg/L). This study suggests that serum TfR measurement is a reliable index of iron depletion and potentially of importance in the diagnosis of iron-deficiency anemia.
The following articles in journals at HighWire Press have cited this article:
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F. Corazza, Y. Beguin, P. Bergmann, M. Andre, A. Ferster, C. Devalck, P. Fondu, M. Buyse, and E. Sariban Anemia in Children With Cancer Is Associated With Decreased Erythropoietic Activity and Not With Inadequate Erythropoietin Production Blood, September 1, 1998; 92(5): 1793 - 1798. [Abstract] [Full Text] [PDF]
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B. S. Skikne Circulating Transferrin Receptor Assay—Coming of Age Clin. Chem., January 1, 1998; 44(1): 7 - 9. [Full Text] [PDF]
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J. Allen, K. R. Backstrom, J. A. Cooper, M. C. Cooper, T. C. Detwiler, D. W. Essex, R. P. Fritz, R. T. Means Jr., P. B. Meier, S. R. Pearlman, et al. Measurement of soluble transferrin receptor in serum of healthy adults Clin. Chem., January 1, 1998; 44(1): 35 - 39. [Abstract] [Full Text] [PDF]
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A. E. Mast, M. A. Blinder, A. M. Gronowski, C. Chumley, and M. G. Scott Clinical utility of the soluble transferrin receptor and comparison with serum ferritin in several populations Clin. Chem., January 1, 1998; 44(1): 45 - 51. [Abstract] [Full Text] [PDF]
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P. Suominen, K. Punnonen, A. Rajamaki, and K. Irjala Evaluation of new immunoenzymometric assay for measuring soluble transferrin receptor to detect iron deficiency in anemic patients Clin. Chem., September 1, 1997; 43(9): 1641 - 1646. [Abstract] [Full Text] [PDF]
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E. Gimferrer, J. Ubeda, M.T. Royo, G.J. Marigo, N. Marco, N. Fernandez, A. Oliver, R. Padros, and I. Gich Serum Transferrin Receptor Levels in Different Stages of Iron Deficiency Blood, August 1, 1997; 90(3): 1332 - 1333. [Full Text] [PDF]
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K. Punnonen, K. Irjala, and A. Rajamaki Serum Transferrin Receptor and Its Ratio to Serum Ferritin in the Diagnosis of Iron Deficiency Blood, February 1, 1997; 89(3): 1052 - 1057. [Abstract] [Full Text] [PDF]
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