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Clinical Chemistry, Vol 40, 796-802, Copyright © 1994 by American Association for Clinical Chemistry
AH Wu, I Laios, S Green, TG Gornet, SS Wong, L Parmley, AS Tonnesen, B Plaisier and R Orlando
Clinical Chemistry Laboratory, Hartford Hospital, CT 06102.
We compared four immunoassays for serum and urine myoglobin. Within-run CVs were 5-13%, with biases seen between assays. Myoglobin was stable for 1 month in serum and 12 days in urine when the pH was adjusted to between 8.0 and 9.5. Hemoglobin caused no interference. We assayed 91 pairs of serum and timed urine specimens from 41 patients admitted for acute trauma or rhabdomyolysis. Most were treated with mannitol and alkalinization. Upon initial presentations, 21 patients with either low serum myoglobin concentrations (< 400 micrograms/L) or high myoglobin clearances (> or = 4 mL/min) had normal creatinine clearances and no clinical evidence of renal disease. The remaining 20 had low myoglobin clearances. Seven were in rhabdomyolysis-induced acute renal failure, or subsequently developed this complication. We suggest that low myoglobin clearance may indicate a high risk for developing renal failure or may be an early marker for kidney dysfunction. Low myoglobin clearance may prove useful in indicating failure of prophylactic treatment to clear myoglobin.
The following articles in journals at HighWire Press have cited this article:
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  H. de Waard and P. van 't Sant Use of Serum Myoglobin Assays for Urine Myoglobin Measurements Can Cause False-Negative Results Clin. Chem., June 1, 2009; 55(6): 1240 - 1241. [Full Text] [PDF]
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 D. S. Grover, M. G. Atta, J. A. Eustace, T. S. Kickler, and D. M. Fine Lack of clinical utility of urine myoglobin detection by microconcentrator ultrafiltration in the diagnosis of rhabdomyolysis Nephrol. Dial. Transplant., October 1, 2004; 19(10): 2634 - 2638. [Abstract] [Full Text] [PDF]
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F. Lasne, N. Crepin, M. Ashenden, M. Audran, and J. de Ceaurriz Detection of Hemoglobin-Based Oxygen Carriers in Human Serum for Doping Analysis: Screening by Electrophoresis Clin. Chem., February 1, 2004; 50(2): 410 - 415. [Abstract] [Full Text] [PDF]
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A. H.B. Wu, F. S. Apple, W. B. Gibler, R. L. Jesse, M. M. Warshaw, and R. Valdes Jr. National Academy of Clinical Biochemistry Standards of Laboratory Practice: Recommendations for the Use of Cardiac Markers in Coronary Artery Diseases Clin. Chem., July 1, 1999; 45(7): 1104 - 1121. [Abstract] [Full Text] [PDF]
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M. Panteghini and F. Pagani Biological Variation of Myoglobin in Serum Clin. Chem., December 1, 1997; 43(12): 2435 - 2435. [Full Text] [PDF]
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K. R. Copeland, B. Loun, and F. A. Sedor Stability of a Control Material Suitable for Quantitative Measurement of Urine Myoglobin Clin. Chem., November 1, 1997; 43(11): 2202 - 2204. [Full Text]
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