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Clinical Chemistry, Vol 40, 1637-1640, Copyright © 1994 by American Association for Clinical Chemistry
DE Goldstein, RR Little, HM Wiedmeyer, JD England, CL Rohlfing and AL Wilke
Department of Child Health, University of Missouri-Columbia School of Medicine 65212.
To address the question, Do laboratory tests cost money or save money? we have used as a model for discussion a common chronic disease, diabetes mellitus, and a widely used laboratory test, that for glycohemoglobin, a measure of long-term glycemia used to manage diabetic patients. Diabetes mellitus is serious, highly prevalent, and costly. In 1992, $1 of every $7 spent on health in the US was for diabetes, predominantly for treatment of the chronic complications of the disease. The recently completed Diabetes Control and Complications Trial (DCCT) demonstrated that development and progression of the chronic complications of diabetes are related to the degree of altered glycemia as quantified by determinations of glycohemoglobin. Thus, use of glycohemoglobin testing for routine diabetes care provides an objective measure of a patient's risk for developing diabetic complications. Results of this test can alert patients and health providers to the need for change in the treatment plan. Optimal use of glycohemoglobin testing for diabetes care will require standardization of test results.
The following articles in journals at HighWire Press have cited this article:
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  B. E.K. Klein, R. Klein, P. E. McBride, S. E. Moss, R. J. Prineas, and J. O. Reinke Electrocardiographic Abnormalities in Individuals With Long-Duration Type 1 Diabetes Diabetes Care, January 1, 2005; 28(1): 145 - 147. [Full Text] [PDF]
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 E. S Kilpatrick Glycated haemoglobin in the year 2000 J. Clin. Pathol., May 1, 2000; 53(5): 335 - 339. [Full Text] [PDF]
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 J. Dalewitz, N. Khan, and C. O. Hershey Barriers to Control of Blood Glucose in Diabetes Mellitus American Journal of Medical Quality, January 1, 2000; 15(1): 16 - 25. [Abstract] [PDF]
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 T. Watanabe, K. Kato, D. Yamada, S. Midorikawa, W. Sato, M. Shiga, Y. Otsuka, M. Miura, K. Harano, and T. Harano A Nondiabetic Case of Hemoglobin Variant (Hb Niigata) with Inappropriately High and Low HbA1c Titers Detected by Different Methods Clin. Chem., July 1, 1998; 44(7): 1562 - 1564. [Full Text] [PDF]
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E. Gerlo and F. Gorus Calibration of ion-exchange HPLC measurements of glycohemoglobin: effect on interassay precision Clin. Chem., December 1, 1997; 43(12): 2353 - 2357. [Abstract] [Full Text] [PDF]
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K. Miedema Electrospray Mass Spectrometry for Measurement of Glycohemoglobin Clin. Chem., May 1, 1997; 43(5): 705 - 707. [Full Text] [PDF]
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G. Halwachs-Baumann, S. Katzensteiner, W. Schnedl, P. Purstner, T. Pieber, and M. Wilders-Truschnig Comparative evaluation of three assay systems for automated determination of hemoglobin A1c Clin. Chem., March 1, 1997; 43(3): 511 - 517. [Abstract] [Full Text] [PDF]
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