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Clinical Chemistry, Vol 40, 1641-1651, Copyright © 1994 by American Association for Clinical Chemistry
AS Rosman and CS Lieber
Alcohol Research & Treatment Center, Bronx Veterans Affairs Medical Center, NY 10468.
Alcoholic liver disease is an important health problem in the US. A public health approach is proposed, using laboratory tests to identify patients with early fibrosis of the liver. A variety of serological markers of liver fibrosis based on collagen-related products (e.g., amino-terminal propeptides of type III procollagen) have been investigated. Further studies are needed to determine the optimal combination of tests for discriminating between steatosis and early fibrosis. Laboratory tests are also useful in excluding nonalcoholic liver diseases such as viral hepatitis, hemochromatosis, and Wilson disease. The monitoring of sobriety in patients with alcoholic liver disease by currently available tests is far from ideal. A new marker of excessive alcohol consumption, carbohydrate-deficient transferrin, is not usually affected by liver disease and thus shows promise as a marker of relapse in alcoholic patients. The development of reliable screening markers of fibrosis and sobriety could potentially reduce the health costs and suffering associated with the complications of alcoholic cirrhosis.
The following articles in journals at HighWire Press have cited this article:
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I. Ryden, P. Pahlsson, and S. Lindgren Diagnostic Accuracy of {alpha}1-Acid Glycoprotein Fucosylation for Liver Cirrhosis in Patients Undergoing Hepatic Biopsy Clin. Chem., December 1, 2002; 48(12): 2195 - 2201. [Abstract] [Full Text] [PDF]
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B. Wuyts, J. R. Delanghe, I. Kasvosve, A. Wauters, H. Neels, and J. Janssens Determination of Carbohydrate-deficient Transferrin Using Capillary Zone Electrophoresis Clin. Chem., February 1, 2001; 47(2): 247 - 255. [Abstract] [Full Text] [PDF]
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K. Viitala, K. Lahdesmaki, and O. Niemela Comparison of the Axis %CDT TIA and the CDTect method as laboratory tests of alcohol abuse Clin. Chem., June 1, 1998; 44(6): 1209 - 1215. [Abstract] [Full Text] [PDF]
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