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Clinical Chemistry, Vol 40, 1674-1685, Copyright © 1994 by American Association for Clinical Chemistry
AM Rose and R Valdes Jr
Department of Pathology, University of Louisville School of Medicine, KY 40292.
Na,K-ATPase (sodium pump; EC 3.6.1.37) is present in the membrane of most eukaryotic cells and controls directly or indirectly many essential cellular functions. Regulation of this enzyme (ion transporter) and its individual isoforms is believed to play a key role in the etiology of some pathological processes. The sodium pump is the only known receptor for the cardiac glycosides. However, endogenous ligands structurally similar to digoxin or ouabain may control the activity of this important molecular complex. Here we review the structure and function of Na,K-ATPase, its expression and distribution in tissues, and its interaction with known ligands such as the cardiac glycosides and other suspected endogenous regulators. Also reviewed are various disorders, including cardiovascular, neurological, renal, and metabolic diseases, purported to involve dysfunction of Na,K-ATPase activity. The escalation in knowledge at the molecular level concerning sodium pump function foreshadows application of this knowledge in the clinical laboratory to identify individuals at risk for Na,K-ATPase- associated diseases.
The following articles in journals at HighWire Press have cited this article:
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H. M.A.M. Qazzaz, Z. Cao, D. D. Bolanowski, B. J. Clark, and R. Valdes Jr De Novo Biosynthesis and Radiolabeling of Mammalian Digitalis-Like Factors Clin. Chem., March 1, 2004; 50(3): 612 - 620. [Abstract] [Full Text] [PDF]
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P. H. Johnson, R. P. Walker, S. W. Jones, K. Stephens, J. Meurer, D. A. Zajchowski, M. M. Luke, F. Eeckman, Y. Tan, L. Wong, et al. Multiplex Gene Expression Analysis for High-Throughput Drug Discovery: Screening and Analysis of Compounds Affecting Genes Overexpressed in Cancer Cells Mol. Cancer Ther., December 1, 2002; 1(14): 1293 - 1304. [Abstract] [Full Text] [PDF]
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M. A. El-Masri, B. J. Clark, H. M. Qazzaz, and R. Valdes Jr Human Adrenal Cells in Culture Produce Both Ouabain-like and Dihydroouabain-like Factors Clin. Chem., October 1, 2002; 48(10): 1720 - 1730. [Abstract] [Full Text] [PDF]
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 J. Chaudhary, M. Walia, J. Matharu, E. Escher, and A. K. Grover Caloxin: a novel plasma membrane Ca2+ pump inhibitor Am J Physiol Cell Physiol, April 1, 2001; 280(4): C1027 - C1030. [Abstract] [Full Text] [PDF]
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 H. M. A. M. Qazzaz, M. A. El-Masri, and R. Valdes Jr. Secretion of a Lactone-Hydrogenated Ouabain-Like Effector of Sodium, Potassium-Adenosine Triphosphatase Activity by Adrenal Cells Endocrinology, September 1, 2000; 141(9): 3200 - 3209. [Abstract] [Full Text] [PDF]
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D. J. McConkey, Y. Lin, L. K. Nutt, H. Z. Ozel, and R. A. Newman Cardiac Glycosides Stimulate Ca2+ Increases and Apoptosis in Androgen-independent, Metastatic Human Prostate Adenocarcinoma Cells Cancer Res., July 1, 2000; 60(14): 3807 - 3812. [Abstract] [Full Text]
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A. M. Rose, H. M. Qazzaz, N. Zolotarjova, B. J. Mellett, A. W. Martin, and R. Valdes Jr Sodium Pump Isoforms in Xenotransplantation: Importance of Biochemical Compatibility Clin. Chem., February 1, 2000; 46(2): 234 - 241. [Abstract] [Full Text] [PDF]
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R. Valdes Jr., S. A. Jortani, and M. Gheorghiade Standards of laboratory practice: cardiac drug monitoring Clin. Chem., May 1, 1998; 44(5): 1096 - 1109. [Abstract] [Full Text] [PDF]
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 T. A Schmidt and K. Kjeldsen Human myocardial Na,K-ATPase -- quantification, regulation and relation to Ca Cardiovasc Res, February 1, 1998; 37(2): 335 - 345. [Full Text] [PDF]
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B. Vasarhelyi, T. Szabo, A. Ver, and T. Tulassay Measurement of Na+/K+-ATPase Activity with an Automated Analyzer Clin. Chem., October 1, 1997; 43(10): 1986 - 1987. [Full Text]
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H. M. A. M. Qazzaz, S. L. Goudy, and R. Valdes Jr. Deglycosylated Products of Endogenous Digoxin-like Immunoreactive Factor in Mammalian Tissue J. Biol. Chem., April 12, 1996; 271(15): 8731 - 8737. [Abstract] [Full Text] [PDF]
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