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Clinical Chemistry 41: 139-146, 1995;
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Clinical Chemistry, Vol 41, 139-146, Copyright © 1995 by American Association for Clinical Chemistry

Role of low-density lipoproteins in atherogenesis and development of coronary heart disease

SM Grundy
Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas 75235-9052.

There is a strong association between increased blood concentrations of low-density lipoprotein (LDL) and severity of coronary atherosclerosis. Multiple mechanisms affect hypercholesterolemia, e.g., diet, aging, hormones, and genetics. LDL receptors apparently are also important-- through down-regulation, defects in structure, or decreased numbers--as are changes in LDL binding characteristics caused by alterations in apolipoprotein B content or structure. Current concepts of LDL metabolism are extensively reviewed, including the role of modified or oxidized LDL in atherogenesis.


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