Clinical Chemistry, Vol 41, 165-169, Copyright © 1995 by American Association for Clinical Chemistry

Relation of high-density lipoprotein subfractions and apolipoprotein E isoforms to coronary disease

PW Wilson
Framingham Heart Study, Framingham, MA 01701.

Although a variety of methods have become available for the determination of high-density lipoprotein (HDL) subfractions in plasma, a review of published data from nine studies of coronary disease outcomes and 10 investigations of coronary artery disease severity do no suggest that measurement of HDL2-cholesterol (C) and HDL3-C offer any advantage in the prediction of coronary disease over the determination of total HDL-C alone. Apolipoprotein E is typically present in plasma as one of six isoforms, the six being encoded by three common alleles, epsilon 2, epsilon 3, and epsilon 4. The epsilon 3 allele is the most common, the epsilon 4 allele has been reported to be associated with higher cholesterol concentrations, and the epsilon 2 and epsilon 4 alleles are both associated with higher triglyceride concentrations. Clinical and arteriographic studies of coronary disease suggest that vascular disease risk is increased among persons with the epsilon 4 allele.

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				Q. Yang, C.-Q. Lai, L. Parnell, L. A. Cupples, X. Adiconis, Y. Zhu, P. W. F. Wilson, D. E. Housman, A. M. Shearman, R. B. D'Agostino, et al. Genome-wide linkage analyses and candidate gene fine mapping for HDL3 cholesterol: the Framingham Study J. Lipid Res., July 1, 2005; 46(7): 1416 - 1425. [Abstract] [Full Text] [PDF]

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