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Clinical Chemistry, Vol 41, 82-86, Copyright © 1995 by American Association for Clinical Chemistry
CW Weykamp, TJ Penders, K Miedema, FA Muskiet and W van der Slik
Department of Clinical Chemistry, Queen Beatrix Hospital, Winterswijk, The Netherlands.
We investigated the effect of calibration with lyophilized calibrators on whole-blood glycohemoglobin (glyHb) results. One hundred three laboratories, using 20 different methods, determined glyHb in two lyophilized calibrators and two whole-blood samples. For whole-blood samples with low (5%) and high (9%) glyHb percentages, respectively, calibration decreased overall interlaboratory variation (CV) from 16% to 9% and from 11% to 6% and decreased intermethod variation from 14% to 6% and from 12% to 5%. Forty-seven laboratories, using 14 different methods, determined mean glyHb percentages in self-selected groups of 10 nondiabetic volunteers each. With calibration their overall mean (2SD) was 5.0% (0.5%), very close to the 5.0% (0.3%) derived from the reference method used in the Diabetes Control and Complications Trial. In both experiments the Abbott IMx and Vision showed deviating results. We conclude that, irrespective of the analytical method used, calibration enables standardization of glyHb results, reference values, and interpretation criteria.
The following articles in journals at HighWire Press have cited this article:
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  A H Berg and D B Sacks Haemoglobin A1c analysis in the management of patients with diabetes: from chaos to harmony J. Clin. Pathol., September 1, 2008; 61(9): 983 - 987. [Abstract] [Full Text] [PDF]
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E. Gerlo and F. Gorus Calibration of ion-exchange HPLC measurements of glycohemoglobin: effect on interassay precision Clin. Chem., December 1, 1997; 43(12): 2353 - 2357. [Abstract] [Full Text] [PDF]
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C. A. Cull, S. E. Manley, I. M. Stratton, H. A. W. Neil, I. S. Ross, R. R. Holman, R. C. Turner, and D. R. Matthews Approach to maintaining comparability of biochemical data during long-term clinical trials Clin. Chem., October 1, 1997; 43(10): 1913 - 1918. [Abstract] [Full Text] [PDF]
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U. Kobold, J.-O. Jeppsson, T. Dulffer, A. Finke, W. Hoelzel, and K. Miedema Candidate reference methods for hemoglobin A1c based on peptide mapping Clin. Chem., October 1, 1997; 43(10): 1944 - 1951. [Abstract] [Full Text] [PDF]
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K. Miedema Electrospray Mass Spectrometry for Measurement of Glycohemoglobin Clin. Chem., May 1, 1997; 43(5): 705 - 707. [Full Text] [PDF]
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N. B. Roberts, B. N. Green, and M. Morris Potential of electrospray mass spectrometry for quantifying glycohemoglobin Clin. Chem., May 1, 1997; 43(5): 771 - 778. [Abstract] [Full Text] [PDF]
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