Clinical Chemistry, Vol 41, 87-91, Copyright © 1995 by American Association for Clinical Chemistry

Solubility of silver sulfadiazine in physiological media and relevance to treatment of thermal burns with silver sulfadiazine cream

N Tsipouras, CJ Rix and PH Brady
Department of Applied Chemistry, Royal Melbourne Institute of Technology, Victoria, Australia.

Silver sulfadiazine cream has been a standard treatment for burns over the past two decades. Although many studies have described the phenomenon of silver absorption from burn wounds treated with silver sulfadiazine, they failed to examine the chemistry underlying the absorption process: Silver chloride was assumed to form at the burn wound and absorption of silver was believed to be negligible. Here we have developed chemical model systems to investigate the interactions of silver sulfadiazine and silver chloride in direct contact with synthetic serum electrolyte solution (SSES), with SSES plus endogenous ligands or beef blood plasma, and with human serum. The results indicate that silver absorption from an acute burn site can be significant, because human serum is capable of solubilizing silver. This finding is of concern, given the potential for silver toxicity as a direct consequence of applying silver sulfadiazine to extensive burn wounds.

The following articles in journals at HighWire Press have cited this article:

				N. Tsipouras, C. J. Rix, and P. H. Brady Passage of silver ions through membrane-mimetic materials, and its relevance to treatment of burn wounds with silver sulfadiazine cream Clin. Chem., February 1, 1997; 43(2): 290 - 301. [Abstract] [Full Text] [PDF]