Clinical Chemistry
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Clinical Chemistry 41: 1614-1616, 1995;
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Clinical Chemistry, Vol 41, 1614-1616, Copyright © 1995 by American Association for Clinical Chemistry

False-positive and false-negative rates in meconium drug testing

C Moore, D Lewis and J Leikin
US Drug Testing Laboratories, Chicago, IL 60612, USA.

To determine the number of false-negative results produced by inefficient extraction of drugs from meconium, three published procedures were compared by using previously confirmed positive and negative meconium specimens. The methods were not equivalent in their ability to extract drugs from the matrix. To determine the number of false positives reported by the use of screen-only (unconfirmed) results, 535 screen-positive meconium specimens were subjects to confirmation by gas chromatography-mass spectrometry. Fifty-seven percent of the samples were confirmed positive for one or more of the drugs under investigation, showing that a false-positive rate as high as 43% may exist when unconfirmed screening results are used.


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[Abstract] [Full Text]


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Copyright © 1995 by the American Association for Clinical Chemistry.