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Clinical Chemistry 41: 1649-1653, 1995;
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Clinical Chemistry, Vol 41, 1649-1653, Copyright © 1995 by American Association for Clinical Chemistry

Analyzer-dependent differences in results for ionized calcium, ionized magnesium, sodium, and pH

EN Hristova, S Cecco, JE Niemela, NN Rehak and RJ Elin
Clinical Pathology Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.

We compared two ion-selective analyzers (AVL 988-4 and NOVA CRT) for determining ionized calcium (iCa2+), ionized magnesium (iMg2+), sodium (Na+), and pH in serum specimens from healthy and diseased individuals. For assays of three levels of protein-based control materials, total imprecision (CV) was < 3% for all analytes except iMg2+ (< or = 6.5% on NOVA, and < or = 4.9% on AVL). We found a significant difference between the analyzers (P < 0.001) for the mean iMg2+ concentration in patients but no significant correlation (r = 0.253) between the analyzers for iMg2+ in specimens from healthy volunteers, even though the mean iMg2+ concentration did not differ significantly between these groups. The reference interval (central 95 percentiles) for iMg2+ with AVL (0.44-0.60 mmol/L) was contained within that of NOVA (0.39-0.64 mmol/L). The AVL gave higher values for iCa2+ (P < 0.001) and lower values for pH (P < 0.001) in specimens from normal volunteers and patients. The mean value for Na+ in patients' samples was significantly higher by the NOVA (P < 0.01) than by the AVL analyzer. Thus, we found significant differences between these two analyzers for all four analytes.


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F. Zoppi and C. Cristalli
Ionized Magnesium in Serum and Ultrafiltrate: pH and Bicarbonate Effect on Measurements with the AVL 988-4 Electrolyte Analyzer
Clin. Chem., March 1, 1998; 44(3): 668 - 671.
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N. N. Rehak, S. A. Cecco, J. E. Niemela, and R. J. Elin
Thiocyanate in smokers interferes with the Nova magnesium ion-selective electrode
Clin. Chem., September 1, 1997; 43(9): 1595 - 1600.
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E. N. Hristova, N. N. Rehak, S. Cecco, M. Ruddel, D. Herion, M. Eckardt, M. Linnoila, and R. J. Elin
Serum ionized magnesium in chronic alcoholism: is it really decreased?
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