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Clinical Chemistry 41: 1716-1719, 1995;
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Clinical Chemistry, Vol 41, 1716-1719, Copyright © 1995 by American Association for Clinical Chemistry

Plasma alpha-glutathione S-transferase assessed as a marker of liver damage in patients with chronic hepatitis C

M Vaubourdolle, O Chazouilleres, I Briaud, C Legendre, L Serfaty, R Poupon and J Giboudeau
Service de Biochimie A, Hopital Saint-Antoine, Paris, France.

alpha-Glutathione S-transferase (alpha-GST; EC 2.5.1.18) has been advocated as a better marker of hepatocellular damage than the transaminases in toxic and autoimmune hepatitis. We have assessed the potential interest of plasma alpha-GST determination in 94 anti- hepatitis C virus-positive patients with histologically proven chronic hepatitis C (34 women, 60 men, ages 40.0 +/- 11.9 years). Blood samples were assayed for aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyltransferase, alkaline phosphatase, and alpha-GST on the same day a liver biopsy was performed. alpha-GST concentrations were significantly above reference values in 64% of patients (compared with 58% for AST, 68% for ALT), and this increase was seen in 52% of patients with normal values for transaminases and a Knodell score > 3. Furthermore, there was a significant correlation between alpha-GST and lobular necrosis score (r = 0.31; P < 0.01). Our findings suggest that association of plasma alpha-GST with ALT may improve the biochemical assessment of liver damage in patients with chronic hepatitis C.


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