Clinical Chemistry
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Clinical Chemistry 41: 343-360, 1995;
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Clinical Chemistry, Vol 41, 343-360, Copyright © 1995 by American Association for Clinical Chemistry

Clinical utility of biochemical analysis of cerebrospinal fluid [published erratum appears in Clin Chem 1995 Aug;41(8 Pt 1):1207]

MA Watson and MG Scott
Washington University School of Medicine, Department of Pathology, St. Louis, MO 63110.

In addition to microbial culture, cytology, and immunological studies, physicians rely on the clinical chemistry laboratory for biochemical analysis of patients' cerebrospinal fluid (CSF). However, apart from routine glucose and protein determinations, the clinical value of other CSF analytes is often unclear. Here, we review the literature pertaining to the use of CSF biochemical measurements in managing patients with infectious disease, neoplasia, stroke and trauma, and dementia. Although a small number of studies demonstrate potential usefulness of some markers, we conclude that, without further study, the data are insufficient to support the routine clinical use of most of the analytes examined.


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