Clinical Chemistry
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 41: 439-443, 1995;
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Castaldo, G.
Right arrow Articles by Sacchetti, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Castaldo, G.
Right arrow Articles by Sacchetti, L.

Clinical Chemistry, Vol 41, 439-443, Copyright © 1995 by American Association for Clinical Chemistry

Discriminant function based on serum analytes differentiates hepatocarcinoma from secondary liver neoplasia

G Castaldo, G Oriani, L Cimino, M Topa, G Budillon, F Salvatore and L Sacchetti
Dipartimento di Biochimica e Biotecnologie Mediche, Facolta di Medicina e Chirurgia, Universita di Napoli Federico II, Italy.

Hepatocellular carcinoma (HC) is often difficult to distinguish from secondary liver neoplasia (SLN) by physical and imaging diagnostic procedures alone. To this aim we have extended and improved a laboratory approach based on a serum lactate dehydrogenase isoenzyme ratio (LD4:LD5) by adding the carcinoembryonic antigen: alpha- fetoprotein ratio, alkaline phosphatase, and serum iron concentrations to obtain a highly efficient discriminant function. In two successive cohorts, for a total of 102 patients, all histologically diagnosed, with a prevalence of HC vs SLN of 3:1, we correctly classified 96% of cases (100% of SLN cases). Subsequent verification with the jackknife reallocation statistical algorithm confirmed these results. In conclusion, this discriminant function based on simple laboratory assays of a few analytes is an important tool in solving a diagnostic dilemma in cases of liver neoplasia.


The following articles in journals at HighWire Press have cited this article:


Home page
 Clin. Chem.Home page
G. Fortunato, G. Castaldo, G. Oriani, R. Cerini, M. Intrieri, E. Molinaro, I. Gentile, G. Borgia, M. Piazza, F. Salvatore, et al.
Multivariate Discriminant Function Based on Six Biochemical Markers in Blood Can Predict the Cirrhotic Evolution of Chronic Hepatitis
Clin. Chem., September 1, 2001; 47(9): 1696 - 1700.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
G. Castaldo, M. Intrieri, L. Castellano, I. de Sio, C. Del Vecchio Blanco, L. Sacchetti, and F. Salvatore
Serum {gamma}-Glutamyltransferase Isoform Complexed to LDL in the Diagnosis of Small Hepatocellular Carcinoma
Clin. Chem., July 1, 1999; 45(7): 1100 - 1102.
[Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1995 by the American Association for Clinical Chemistry.