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Clinical Chemistry 41: 462-464, 1995;
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Clinical Chemistry, Vol 41, 462-464, Copyright © 1995 by American Association for Clinical Chemistry

Decreased amino acid uptake by erythrocytes during postoperative sepsis

NB Roberts and R Wilkes
Department of Clinical Chemistry, Royal Liverpool University Hospital, UK.

We describe a patient with postoperative sepsis associated with reduced ability to transport amino acids into erythrocytes. Administration of amino acid infusion showed no effect on plasma or red blood cell concentrations of the amino acids during the sepsis period. However, when the site of sepsis was removed, patient recovery was associated with marked increases of all amino acids, particularly in the red blood cells. The case illustrates the potential of red blood cells as a marker of amino acid utilization and demonstrates the association of sepsis with effects on cellular uptake.




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Copyright © 1995 by the American Association for Clinical Chemistry.