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Clinical Chemistry, Vol 41, 495-509, Copyright © 1995 by American Association for Clinical Chemistry
JP Landers
Department of Laboratory Medicine and Pathology, Mayo Clinic/Foundation, Rochester, MN 55905, USA.
Capillary electrophoresis is a relatively new analytical technique that has begun to have an impact in the clinical laboratory, both for routine analyses and for those that are more esoteric. Its potential for automated, rapid, high-efficiency separations makes it appealing as a replacement for some of the more labor-intensive assays carried out in electrophoretic gels and as a complement to companion techniques such as HPLC. Among the many attractive characteristics of this technology is its versatility for analyses of a diverse spectrum of analytes, ranging from small organic ions to macromolecular protein complexes or DNA. The focus of this commentary is to familiarize the clinical scientist with the instrumentation and principles of capillary electrophoretic separation and to review the recent research demonstrating the applicability of this technology to the clinical laboratory.
The following articles in journals at HighWire Press have cited this article:
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  W. T. Hofgartner, A. F.R. Huhmer, J. P. Landers, and J. A. Kant Rapid Diagnosis of Herpes Simplex Encephalitis Using Microchip Electrophoresis of PCR Products Clin. Chem., December 1, 1999; 45(12): 2120 - 2128. [Abstract] [Full Text] [PDF]
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S. Hustad, P. M. Ueland, and J. Schneede Quantification of Riboflavin, Flavin Mononucleotide, and Flavin Adenine Dinucleotide in Human Plasma by Capillary Electrophoresis and Laser-induced Fluorescence Detection Clin. Chem., June 1, 1999; 45(6): 862 - 868. [Abstract] [Full Text] [PDF]
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N. Mario, B. Baudin, A. Bruneel, J. Janssens, and M. Vaubourdolle Capillary Zone Electrophoresis for the Diagnosis of Congenital Hemoglobinopathies Clin. Chem., February 1, 1999; 45(2): 285 - 288. [Full Text] [PDF]
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X. Bossuyt, A. Mewis, and N. Blanckaert Interference of Radio-opaque Agents in Clinical Capillary Zone Electrophoresis Clin. Chem., January 1, 1999; 45(1): 129 - 131. [Full Text] [PDF]
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X. Bossuyt, G. Schiettekatte, A. Bogaerts, and N. Blanckaert Serum protein electrophoresis by CZE 2000 clinical capillary electrophoresis system Clin. Chem., April 1, 1998; 44(4): 749 - 759. [Abstract] [Full Text] [PDF]
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X. Bossuyt, A. Bogaerts, G. Schiettekatte, and N. Blanckaert Detection and classification of paraproteins by capillary immunofixation/subtraction Clin. Chem., April 1, 1998; 44(4): 760 - 764. [Abstract] [Full Text] [PDF]
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J. Bienvenu, M. S. Graziani, F. Arpin, H. Bernon, C. Blessum, C. Marchetti, G. Righetti, M. Somenzini, G. Verga, and F. Aguzzi Multicenter evaluation of the Paragon CZETM 2000 capillary zone electrophoresis system for serum protein electrophoresis and monoclonal component typing Clin. Chem., March 1, 1998; 44(3): 599 - 605. [Abstract] [Full Text] [PDF]
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P. Carrera, A. M. Barbieri, M. Ferrari, P. G. Righetti, M. Perego, and C. Gelfi Rapid detection of 21-hydroxylase deficiency mutations by allele-specific in vitro amplification and capillary zone electrophoresis Clin. Chem., November 1, 1997; 43(11): 2121 - 2127. [Abstract] [Full Text] [PDF]
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N. Mario, B. Baudin, C. Aussel, and J. Giboudeau Capillary isoelectric focusing and high-performance cation-exchange chromatography compared for qualitative and quantitative analysis of hemoglobin variants Clin. Chem., November 1, 1997; 43(11): 2137 - 2142. [Abstract] [Full Text] [PDF]
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