Clinical Chemistry
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Clinical Chemistry 41: 510-514, 1995;
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Clinical Chemistry, Vol 41, 510-514, Copyright © 1995 by American Association for Clinical Chemistry

Four agglutination assays evaluated for measurement of von Willebrand factor (ristocetin cofactor activity)

AA Ermens, PJ de Wild, HL Vader and F van der Graaf
Clinical Laboratories, Saint Joseph Hospital, Veldhoven, The Netherlands.

The concentration of von Willebrand factor (vWf) in patients' plasma can be determined by measuring the ristocetin cofactor activity (vWf R:Co). However, this vWf R:Co assay is time consuming, which limits its routine use. Several commercial vWf R:Co tests, based on agglutination of lyophilized fixed platelets, are available. We evaluated the slide tests and aggregometer assays from Behring and Organon Teknika and compared them with the classic vWf R:Co aggregometer method. The within- run and between-run precisions of the two slide tests were better than those of the aggregometer methods. The correlation studies between the four commercial assays and the classic aggregation method were based on 23 plasma samples (range: 15-450% vWf R:Co). The correlation coefficients, which ranged from 0.923 to 0.950, did not differ significantly (P > 0.1). All four commercial assays gave significantly lower vWf R:Co values than the classic aggregation method (P < 0.01). We conclude that commercially available fixed platelets can be used for the rapid measurement of vWf R:Co with a slide test. The use of the aggregometer is time consuming and may result in a lower precision.


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E. J. Favaloro, P. A. Mehrabani, and J. Koutts
Laboratory Assessment of von Willebrand Factor: Altered Interpretation of Laboratory Data, and Altered Diagnosis of von Willebrand's Disease
Clinical and Applied Thrombosis/Hemostasis, April 1, 1997; 3(2): 110 - 118.
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Copyright © 1995 by the American Association for Clinical Chemistry.