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Clinical Chemistry 41: 599-604, 1995;
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Clinical Chemistry, Vol 41, 599-604, Copyright © 1995 by American Association for Clinical Chemistry

Simultaneous assessments of exocrine pancreatic function by cholesteryl- [14C]octanoate breath test and measurement of plasma p-aminobenzoic acid

MJ Bruno, FJ Hoek, B Delzenne, DJ van Leeuwen, CD Schteingart, AF Hofmann and GN Tytgat
Department of Gastroenterology, University of Amsterdam, The Netherlands.

Two noninvasive tests for assessing pancreatic exocrine function, the cholesteryl-[14C]octanoate breath test and the HPLCN-benzoyl-tyrosyl-p- aminobenzoic acid/p-aminosalicylic acid (NBT-PABA/PAS) test, were simultaneously performed in nine patients with pancreatic exocrine insufficiency due to chronic pancreatitis and in nine healthy volunteers. 14CO2 output in breath and plasma PABA concentration rose slowly in patients but increased rapidly in healthy subjects. The measurement time giving the best discrimination between both groups was 120 min for the cholesteryl-[14C]octanoate breath test and 90 min for the plasma PABA test. At these points, both single-sample tests had essentially identical diagnostic sensitivity. The diagnostic sensitivities of the two single-sample tests were equal to that of the cumulative 6-h urinary PABA recovery and the cumulative 6-h urinary PABA/PAS ratio. We conclude that, for both the cholesteryl- [14C]octanoate breath test and the plasma PABA test, a single test sample is sufficient for rapid detection of impaired exocrine pancreatic function.


The following articles in journals at HighWire Press have cited this article:


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M Ventrucci, A Cipolla, G M Ubalducci, A Roda, and E Roda
13C labelled cholesteryl octanoate breath test for assessing pancreatic exocrine insufficiency
Gut, January 1, 1998; 42(1): 81 - 87.
[Abstract] [Full Text] [PDF]


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Copyright © 1995 by the American Association for Clinical Chemistry.