Clinical Chemistry
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 41: 1068-1086, 1995;
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Siest, G.
Right arrow Articles by Visvikis, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Siest, G.
Right arrow Articles by Visvikis, S.

Clinical Chemistry, Vol 41, 1068-1086, Copyright © 1995 by American Association for Clinical Chemistry

Apolipoprotein E: an important gene and protein to follow in laboratory medicine

G Siest, T Pillot, A Regis-Bailly, B Leininger-Muller, J Steinmetz, MM Galteau and S Visvikis
Laboratoire du Centre de Medecine Preventive, URA CNRS 597 alliee a l'INSERM, Vandoeuvre Les Nancy, France.

The human apolipoprotein (apo) E gene is polymorphic, with three common alleles (epsilon 2, epsilon 3, epsilon 4) coding for three isoforms (E2, E3, E4). The isoforms differ from each other by a single amino acid substitution, and also differ in their binding affinity for the four apo E receptors. Apo E polymorphism is an important determinant of risk for the development of cardiovascular and Alzheimer diseases, the prevalence of the epsilon 4 allele being increased in both kinds of patients compared with control subjects. Furthermore, the prevalence of the epsilon 4 allele differs among populations (range 5-40%, respectively, for Taiwanese and Papua New Guineans). Genotyping or phenotyping needs to be introduced in clinical laboratories. The choice of the method should be based on the types of patients who are examined. The apo E genotype is also a determinant of apo E plasma concentration. Standardization of apo E measurement is an important prerequisite before investigating the clinical interest of plasma apo E concentration. Determination of apo E genotype/phenotype and later the plasma concentration are expected to yield useful clinical laboratory information.


The following articles in journals at HighWire Press have cited this article:


Home page
 Annals of Clinical & Laboratory ScienceHome page
G. Kolovou, D. Damaskos, K. Anagnostopoulou, and D. V. Cokkinos
Apolipoprotein E Gene Polymorphism and Gender
Ann. Clin. Lab. Sci., January 1, 2009; 39(2): 120 - 133.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. O. Hopkins, L. K. Weaver, K. J. Valentine, C. Mower, S. Churchill, and J. Carlquist
Apolipoprotein E Genotype and Response of Carbon Monoxide Poisoning to Hyperbaric Oxygen Treatment
Am. J. Respir. Crit. Care Med., November 15, 2007; 176(10): 1001 - 1006.
[Abstract] [Full Text] [PDF]

Home page
 AM J ALZHEIMERS DIS OTHER DEMENHome page
C. K. Chai
The Genetics of Alzheimer's Disease
American Journal of Alzheimer's Disease and Other Dementias, February 1, 2007; 22(1): 37 - 41.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
B. Jasinska-Myga, G. Opala, C. G. Goetz, J. Tustanowski, S. Ochudlo, A. Gorzkowska, and J. Tyrpa
Apolipoprotein E Gene Polymorphism, Total Plasma Cholesterol Level, and Parkinson Disease Dementia
Arch Neurol, February 1, 2007; 64(2): 261 - 265.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
D. Seripa, M. Franceschi, M. G. Matera, F. Panza, P. G. Kehoe, C. Gravina, G. Orsitto, V. Solfrizzi, G. Di Minno, B. Dallapiccola, et al.
Sex differences in the association of apolipoprotein e and Angiotensin-converting enzyme gene polymorphisms with healthy aging and longevity: a population-based study from southern Italy.
J. Gerontol. A Biol. Sci. Med. Sci., September 1, 2006; 61(9): 918 - 923.
[Abstract] [Full Text] [PDF]

Home page
 Mult SclerHome page
M Pinholt, J L Frederiksen, P S Andersen, and M Christiansen
Apo E in multiple sclerosis and optic neuritis: the Apo E-o4 allele is associated with progression of multiple sclerosis
Multiple Sclerosis, October 1, 2005; 11(5): 511 - 515.
[Abstract] [PDF]

Home page
 J. Lipid Res.Home page
R. M. Lane and M. R. Farlow
Lipid homeostasis and apolipoprotein E in the development and progression of Alzheimer's disease
J. Lipid Res., May 1, 2005; 46(5): 949 - 968.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
W. Koch, J. Mehilli, A. Pfeufer, A. Schomig, and A. Kastrati
Apolipoprotein E gene polymorphisms and thrombosis and restenosis after coronary artery stenting
J. Lipid Res., December 1, 2004; 45(12): 2221 - 2226.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
G. M. Novaro, R. Sachar, G. L. Pearce, D. L. Sprecher, and B. P. Griffin
Association Between Apolipoprotein E Alleles and Calcific Valvular Heart Disease
Circulation, October 14, 2003; 108(15): 1804 - 1808.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
H. M. Blanck, B. A. Bowman, G. R. Cooper, G. L. Myers, and D. T. Miller
Laboratory Issues: Use of Nutritional Biomarkers
J. Nutr., March 1, 2003; 133(3): 888S - 894.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
T. Lehtimaki, P. Dastidar, H. Jokela, T. Koivula, S. Lehtinen, C. Ehnholm, and R. Punnonen
Effect of Long-Term Hormone Replacement Therapy on Atherosclerosis Progression in Postmenopausal Women Relates to Functional Apolipoprotein E Genotype
J. Clin. Endocrinol. Metab., September 1, 2002; 87(9): 4147 - 4153.
[Abstract] [Full Text] [PDF]

Home page
 Am J EpidemiolHome page
J. E. Eichner, S. T. Dunn, G. Perveen, D. M. Thompson, K. E. Stewart, and B. C. Stroehla
Apolipoprotein E Polymorphism and Cardiovascular Disease: A HuGE Review
Am. J. Epidemiol., March 15, 2002; 155(6): 487 - 495.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
H. Kadotani, T. Kadotani, T. Young, P. E. Peppard, L. Finn, I. M. Colrain, G. M. Murphy Jr, and E. Mignot
Association Between Apolipoprotein E {epsilon}4 and Sleep-Disordered Breathing in Adults
JAMA, June 13, 2001; 285(22): 2888 - 2890.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
M. Schiefermeier, H. Kollegger, C. Madl, C. Schwarz, M. Holzer, J. Kofler, and F. Sterz
Apolipoprotein E Polymorphism : Survival and Neurological Outcome After Cardiopulmonary Resuscitation
Stroke, September 1, 2000; 31(9): 2068 - 2073.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
M. Schiefermeier, H. Kollegger, C. Madl, C. Polli, W. Oder, H.-J. Kuhn, F. Berr, and P. Ferenci
The impact of apolipoprotein E genotypes on age at onset of symptoms and phenotypic expression in Wilson's disease
Brain, March 1, 2000; 123(3): 585 - 590.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
G. Marrazza, G. Chiti, M. Mascini, and M. Anichini
Detection of Human Apolipoprotein E Genotypes by DNA Electrochemical Biosensor Coupled with PCR
Clin. Chem., January 1, 2000; 46(1): 31 - 37.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
M. K. Bolla, N. Wood, and S. E. Humphries
Rapid determination of apolipoprotein E genotype using a heteroduplex generator
J. Lipid Res., December 1, 1999; 40(12): 2340 - 2345.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
C. DeCarli, T. Reed, B. L. Miller, P. A. Wolf, G. E. Swan, and D. Carmelli
Impact of Apolipoprotein E {epsilon}4 and Vascular Disease on Brain Morphology in Men From the NHLBI Twin Study
Stroke, August 1, 1999; 30(8): 1548 - 1553.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
G. G. Donohoe, A. Salomaki, T. Lehtimaki, K. Pulkki, and V. Kairisto
Rapid Identification of Apolipoprotein E Genotypes by Multiplex Amplification Refractory Mutation System PCR and Capillary Gel Electrophoresis
Clin. Chem., January 1, 1999; 45(1): 143 - 146.
[Full Text] [PDF]

Home page
 Clin. Chem.Home page
M. Vincent-Viry, F. Schiele, R. Gueguen, K. Bohnet, S. Visvikis, and G. Siest
Biological variations and genetic reference values for apolipoprotein E serum concentrations: results from the STANISLAS cohort study
Clin. Chem., May 1, 1998; 44(5): 957 - 965.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
C. Kessler, C. Spitzer, D. Stauske, S. Mende, J. Stadlmuller, R. Walther, and R. Rettig
The Apolipoprotein E and ß-Fibrinogen G/A-455 Gene Polymorphisms Are Associated With Ischemic Stroke Involving Large-Vessel Disease
Arterioscler Thromb Vasc Biol, November 1, 1997; 17(11): 2880 - 2884.
[Abstract] [Full Text]

Home page
 Clin. Chem.Home page
Gianluca De Bellis, G. Salani, S. Panigone, F. Betti, L. Invernizzi, and M. Luzzana
Apolipoprotein E genotyping by capillary electrophoretic analysis of restriction fragments
Clin. Chem., August 1, 1997; 43(8): 1321 - 1324.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
S. M. Haffner, M. P. Stern, H. Miettinen, D. Robbins, and B. V. Howard
Apolipoprotein E Polymorphism and LDL Size in a Biethnic Population
Arterioscler Thromb Vasc Biol, September 1, 1996; 16(9): 1184 - 1188.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1995 by the American Association for Clinical Chemistry.