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Clinical Chemistry 41: 1129-1134, 1995;
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Clinical Chemistry, Vol 41, 1129-1134, Copyright © 1995 by American Association for Clinical Chemistry

Amylase, lipase, pancreatic isoamylase, and phospholipase A in diagnosis of acute pancreatitis

P Clave, S Guillaumes, I Blanco, N Nabau, J Merce, A Farre, L Marruecos and F Lluis
Department of Surgery, Institut de Recerca, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.

To determine the utility of serum amylase (AMY), lipase (Lp), pancreatic isoamylase (isoA), phospholipase A (PLA), and urine AMY in the diagnosis of acute pancreatitis, samples of serum and urine were obtained on admission and every day thereafter for 5 days from 384 patients with acute abdominal pain. Diagnostic accuracy, determined as the area under the receiver operating characteristic curve, was > 0.975 for serum AMY, Lp, isoA, and urine AMY. For each of these enzymes, a threshold value (twice to sixfold the upper limit of the reference values) offering diagnostic efficiency > 95% could be determined. In contrast, accuracy and efficiency of serum PLA were low. The profiles of these enzymes in acute pancreatitis decreased in a parallel fashion over 5 days except for PLA. We conclude that diagnostic utilities are similar for serum AMY, Lp, isoA, and urine AMY for acute pancreatitis, provided that an appropriate threshold is established.


The following articles in journals at HighWire Press have cited this article:


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 Emerg. Med. J.Home page
J. Butler and K. Mackway-Jones
Serum amylase or lipase to diagnose pancreatitis in patients presenting with abdominal pain
Emerg. Med. J., September 1, 2002; 19(5): 430 - 431.
[Abstract] [Full Text]

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 Arch Intern MedHome page
S. Ben-Horin, Z. Farfel, and M. Mouallem
Gastroenteritis-Associated Hyperamylasemia: Prevalence and Clinical Significance
Arch Intern Med, March 25, 2002; 162(6): 689 - 692.
[Abstract] [Full Text] [PDF]

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 NEJMHome page
J. A. Grinblatt, E. A. Kemppainen, P. A. Puolakkainen, and U.-H. Stenman
Measurement of Urinary Trypsinogen-2 as a Screening Test for Acute Pancreatitis
N. Engl. J. Med., November 6, 1997; 337(19): 1394 - 1395.
[Full Text]


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