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Clinical Chemistry, Vol 41, 1135-1138, Copyright © 1995 by American Association for Clinical Chemistry
P Jackson, CM Loughrey, JH Lightbody, PT McNamee and IS Young
Department of Clinical Biochemistry, Queen's University of Belfast, Northern Ireland.
Cardiovascular disease is the major cause of mortality in patients receiving hemodialysis for chronic renal failure. Increased lipid peroxidation and depletion of chain-breaking antioxidants may contribute to increased risk of atherosclerosis. We have therefore assessed the effect of a single episode of hemodialysis on antioxidant status in 22 patients and control subjects. Overall, total antioxidant capacity of serum was increased in dialysis patients, but there was a marked reduction after hemodialysis [571 +/- 31 vs 342 +/- 22 mumol/L Trolox (water-soluble vitamin E analog) equivalents, P < 0.001]. The increase in total antioxidant capacity before hemodialysis was almost entirely due to relatively high serum urate. Among individual chain- breaking antioxidants, dialysis led to a decrease in urate (398 +/- 15 vs 136 +/- 12 mumol/L, P < 0.001), ascorbate (10.5 +/- 1.7 vs 5.9 +/- 1.0 mumol/L, P < 0.01), and lipid-corrected tocopherol (4.70 +/- 0.56 vs 4.26 +/- 0.39 mumol/mmol cholesterol, P < 0.05). Protein thiol groups increased after dialysis (328 +/- 16 vs 422 +/- 22 mumol/L, P < 0.001), whereas albumin remained unchanged (40.1 +/- 1.1 vs 41.0 +/- 1.6 g/L, not significant). Although total antioxidant capacity of serum is increased in hemodialysis patients, depletion of key chain-breaking antioxidants may lead to accelerated atherogenesis.
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G. J. Handelman Vitamin C deficiency in dialysis patients--are we perceiving the tip of an iceberg? Nephrol. Dial. Transplant., February 1, 2007; 22(2): 328 - 331. [Full Text] [PDF]
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 I S Young Measurement of total antioxidant capacity J. Clin. Pathol., May 1, 2001; 54(5): 339 - 339. [Full Text] [PDF]
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P. Pinzani, E. Petruzzi, C. Orlando, A. Stefanescu, M. F. Antonini, M. Serio, and M. Pazzagli Reduced Serum Antioxidant Capacity In Healthy Centenarians Clin. Chem., May 1, 1997; 43(5): 855a - 856. [Full Text]
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