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Clinical Chemistry, Vol 42, 164-173, Copyright © 1996 by American Association for Clinical Chemistry
CA Spencer, M Takeuchi and M Kazarosyan
Department of Medicine, University of Southern California, Los Angeles 90033, USA. cspencer@hsc.usc.edu
Serum thyroglobulin (Tg) measurements are used as a tumor marker for monitoring patients with differentiated thyroid carcinoma. The clinical utility of six different Tg methods [RIA or immunometric assay (IMA)] currently used in Europe and the US was evaluated, with focus on methodologic standardization, sensitivity, interassay precision across the typical clinical monitoring interval (6 to 12 months), "hook" effects (IMA methods), and Tg autoantibody interference. The methods evaluated were: DYNOtest Tg (Henning), OptiQuant Tg (Kronus), SELco Tg (Medipan), Thyroglobulin IRMA (Pasteur), Nichols Chemiluminescent ICMA (Corning Nichols), and an RIA developed by us (USC Endocrine Services Laboratory). The clinical impact of the current methodologic problems on the use of serum Tg measurements is reviewed. Optimal performance goals are recommended for manufacturers developing and laboratories and physicians selecting a serum Tg method to use for serial long-term monitoring of thyroid cancer patients.
The following articles in journals at HighWire Press have cited this article:
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  A. C.M. Persoon, T. P. Links, J. Wilde, W. J. Sluiter, B. H.R. Wolffenbuttel, and J. M.W. van den Ouweland Thyroglobulin (Tg) Recovery Testing with Quantitative Tg Antibody Measurement for Determining Interference in Serum Tg Assays in Differentiated Thyroid Carcinoma Clin. Chem., June 1, 2006; 52(6): 1196 - 1199. [Abstract] [Full Text] [PDF]
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A. C.M. Persoon, J. M.W. Van Den Ouweland, J. Wilde, I. P. Kema, B. H.R. Wolffenbuttel, and T. P. Links Clinical utility of an automated immunochemiluminometric thyroglobulin assay in differentiated thyroid carcinoma. Clin. Chem., April 1, 2006; 52(4): 686 - 691. [Abstract] [Full Text] [PDF]
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 K. Zophel, G. Wunderlich, and J. Kotzerke A Highly Sensitive Thyroglobulin Assay Has Superior Diagnostic Sensitivity for Recurrence of Differentiated Thyroid Cancer in Patients Undergoing TSH Suppression J. Nucl. Med., March 1, 2006; 47(3): 552 - 553. [Full Text] [PDF]
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 C. A. Spencer, L. M. Bergoglio, M. Kazarosyan, S. Fatemi, and J. S. LoPresti Clinical Impact of Thyroglobulin (Tg) and Tg Autoantibody Method Differences on the Management of Patients with Differentiated Thyroid Carcinomas J. Clin. Endocrinol. Metab., October 1, 2005; 90(10): 5566 - 5575. [Abstract] [Full Text] [PDF]
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 R Gorges, M Maniecki, W Jentzen, S. n-Y. Sheu, K Mann, A Bockisch, and O E Janssen Development and clinical impact of thyroglobulin antibodies in patients with differentiated thyroid carcinoma during the first 3 years after thyroidectomy Eur. J. Endocrinol., July 1, 2005; 153(1): 49 - 55. [Abstract] [Full Text] [PDF]
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C. A. Spencer Challenges of Serum Thyroglobulin (Tg) Measurement in the Presence of Tg Autoantibodies J. Clin. Endocrinol. Metab., August 1, 2004; 89(8): 3702 - 3704. [Full Text] [PDF]
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R. Elisei, A. Vivaldi, L. Agate, E. Molinaro, C. Nencetti, L. Grasso, A. Pinchera, and F. Pacini Low Specificity of Blood Thyroglobulin Messenger Ribonucleic Acid Assay Prevents Its Use in the Follow-Up of Differentiated Thyroid Cancer Patients J. Clin. Endocrinol. Metab., January 1, 2004; 89(1): 33 - 39. [Abstract] [Full Text] [PDF]
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E. L. Mazzaferri, R. J. Robbins, C. A. Spencer, L. E. Braverman, F. Pacini, L. Wartofsky, B. R. Haugen, S. I. Sherman, D. S. Cooper, G. D. Braunstein, et al. A Consensus Report of the Role of Serum Thyroglobulin as a Monitoring Method for Low-Risk Patients with Papillary Thyroid Carcinoma J. Clin. Endocrinol. Metab., April 1, 2003; 88(4): 1433 - 1441. [Abstract] [Full Text] [PDF]
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N. G. Morgenthaler, J. Froehlich, J. Rendl, M. Willnich, C. Alonso, A. Bergmann, and C. Reiners Technical Evaluation of a New Immunoradiometric and a New Immunoluminometric Assay for Thyroglobulin Clin. Chem., July 1, 2002; 48(7): 1077 - 1083. [Abstract] [Full Text] [PDF]
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C. Massart and D. Maugendre Importance of the Detection Method for Thyroglobulin Antibodies for the Validity of Thyroglobulin Measurements in Sera from Patients with Graves Disease Clin. Chem., January 1, 2002; 48(1): 102 - 107. [Abstract] [Full Text] [PDF]
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E. L. Mazzaferri and R. T. Kloos Current Approaches to Primary Therapy for Papillary and Follicular Thyroid Cancer J. Clin. Endocrinol. Metab., April 1, 2001; 86(4): 1447 - 1463. [Full Text]
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L. A. Perry and A. Dawnay Chemiluminescent Assay for Serum Thyroglobulin in the Management of Patients with Thyroid Carcinoma Clin. Chem., April 1, 2001; 47(4): 778 - 779. [Full Text] [PDF]
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R. P. M. Biscolla, J. M. Cerutti, and R. M. B. Maciel Detection of Recurrent Thyroid Cancer by Sensitive Nested Reverse Transcription-Polymerase Chain Reaction of Thyroglobulin and Sodium/Iodide Symporter Messenger Ribonucleic Acid Transcripts in Peripheral Blood J. Clin. Endocrinol. Metab., October 1, 2000; 85(10): 3623 - 3627. [Abstract] [Full Text]
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M. M. Kaplan Clinical Perspectives in the Diagnosis of Thyroid Disease Clin. Chem., August 1, 1999; 45(8): 1377 - 1383. [Abstract] [Full Text] [PDF]
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C. A. Spencer, M. Takeuchi, M. Kazarosyan, C. C. Wang, R. B. Guttler, P. A. Singer, S. Fatemi, J. S. LoPresti, and J. T. Nicoloff Serum Thyroglobulin Autoantibodies: Prevalence, Influence on Serum Thyroglobulin Measurement, and Prognostic Significance in Patients with Differentiated Thyroid Carcinoma J. Clin. Endocrinol. Metab., April 1, 1998; 83(4): 1121 - 1127. [Abstract] [Full Text]
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C. Calzolari, P.-Y. Marquet, B. Pau, C. A. Spencer, and M. Takeuchi Thyroglobulin IRMA Pasteur Immunoassay: Sensitivity of the Assay and Interference from Thyroglobulin Autoantibodies • The authors of the above-mentioned article and editorial reply: Clin. Chem., February 1, 1997; 43(2): 413 - 415. [Full Text]
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