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Clinical Chemistry, Vol 42, 1689-1694, Copyright © 1996 by American Association for Clinical Chemistry
EW Gunter, BA Bowman, SP Caudill, DB Twite, MJ Adams and EJ Sampson
Division of Environmental Health Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30341-3724, USA.
Because of the increasing significance of folate nutriture to public health, a "round robin" interlaboratory comparison study was conducted to assess differences among methods. Twenty research laboratories participated in a 3-day analysis of six serum and six whole-blood pools. Overall means, SDs, and CVs derived from these results were compared within and across method types. Results reported for serum and whole-blood folate demonstrated overall CVs of 27.6% and 35.7%, respectively, across pools and two- to ninefold differences in concentrations between methods, with the greatest variation occurring at critical low folate concentrations. Although results for serum pools were less variable than those for whole-blood pools, substantial intermethod variation still occurred. The overall results underscore the urgent need for developing and validating reference methods for serum and whole-blood folate and for properly characterized reference materials. For evaluating study or clinical data, method-specific reference ranges (established with clinical confirmation of values for truly folate-deficient individuals) must be used.
The following articles in journals at HighWire Press have cited this article:
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Z. Fazili and C. M. Pfeiffer Measurement of Folates in Serum and Conventionally Prepared Whole Blood Lysates: Application of an Automated 96-Well Plate Isotope-Dilution Tandem Mass Spectrometry Method Clin. Chem., December 1, 2004; 50(12): 2378 - 2381. [Full Text] [PDF]
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C. M. Pfeiffer, Z. Fazili, L. McCoy, M. Zhang, and E. W. Gunter Determination of Folate Vitamers in Human Serum by Stable-Isotope-Dilution Tandem Mass Spectrometry and Comparison with Radioassay and Microbiologic Assay Clin. Chem., February 1, 2004; 50(2): 423 - 432. [Abstract] [Full Text] [PDF]
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E. Hertrampf, F. Cortes, J. D. Erickson, M. Cayazzo, W. Freire, L. B. Bailey, C. Howson, G. P. A. Kauwell, and C. Pfeiffer Consumption of Folic Acid-Fortified Bread Improves Folate Status in Women of Reproductive Age in Chile J. Nutr., October 1, 2003; 133(10): 3166 - 3169. [Abstract] [Full Text] [PDF]
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I. P Fohr, R. Prinz-Langenohl, A. Bronstrup, A. M Bohlmann, H. Nau, H. K Berthold, and K. Pietrzik 5,10-Methylenetetrahydrofolate reductase genotype determines the plasma homocysteine-lowering effect of supplementation with 5-methyltetrahydrofolate or folic acid in healthy young women Am. J. Clinical Nutrition, February 1, 2002; 75(2): 275 - 282. [Abstract] [Full Text] [PDF]
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