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Clinical Chemistry 42: 1789-1795, 1996;
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Clinical Chemistry, Vol 42, 1789-1795, Copyright © 1996 by American Association for Clinical Chemistry

Growth hormone assays: early to latest test generations compared

M L'Hermite-Baleriaux, G Copinschi and E Van Cauter
Center for the Study of Biological Rhythms (CERB), School of Medicine, Universite Libre de Bruxelles, Belgium. mbaleria@med.ulb.ac.be

We compared the data from four growth hormone (GH) immunoassays for analyzing 24-h GH profiles in four apparently normal subjects and four obese subjects (508 serum samples). The detection limit was 0.02 microgram/L for one immunochemiluminometric assay (ICMA), 0.1 microgram/L for two IRMAs, and 0.4 microgram/L for one RIA. All GH pulses with a peak ICMA value > 1 microgram/L were detected by each of the other methods. Overall, the correlation coefficient between the values obtained with all four assays exceeded 0.90. However, for GH concentrations < or = 0.25 microgram/L, acceptable concordance (r2 > or = 0.80) was reached only between the ICMA and one IRMA; between the ICMA and the RIA, concordance was acceptable only for GH concentrations > or = 10 micrograms/L. In the normal subjects, the percentage of undetectable values was 0% with the ICMA but 29% with one of the IRMAs; in obese subjects, the corresponding values were 12% and 38%.


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