Clinical Chemistry AACC Online Job Center
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 42: 1855-1860, 1996;
This Article
Right arrow Full Text (PDF)
Right arrow Submit an electronic Letter to
the Editor about this paper
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Muller, F.
Right arrow Articles by Dumez, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Muller, F.
Right arrow Articles by Dumez, Y.

Clinical Chemistry, Vol 42, 1855-1860, Copyright © 1996 by American Association for Clinical Chemistry

Development of human renal function: reference intervals for 10 biochemical markers in fetal urine

F Muller, M Dommergues, L Bussieres, S Lortat-Jacob, C Loirat, JF Oury, Y Aigrain, P Niaudet, P Aegerter and Y Dumez
Hopital Ambroise Pare, Boulogne, Universite Paris V, France.

Evaluation of fetal renal function by analysis of fetal urine sampled in utero may improve perinatal care after a prenatal diagnosis of bilateral obstructive uropathy. We provide reference intervals for 10 fetal urinary compounds and examine their variation with gestational age. Forty-one fetuses with bilateral obstructive uropathy (urine sampled between 20 and 38 weeks of gestational age) had normal, healthy values for serum creatinine (< or = 50 mumol/L) at ages 1-2 years. These cases were thus assumed to represent a reasonable approximation to healthy values. Sodium and beta 2-microglobulin concentrations significantly decreased with gestational age; calcium, ammonia, and creatinine significantly increased; glucose, phosphorus, chloride, urea, and total protein concentrations did not vary. Our results provide reference values for prenatal evaluation of fetal renal function and suggest that glomerular filtration of macromolecules and tubular reabsorption of glucose and phosphorus are mature by 20 weeks of gestation, whereas tubular reabsorption of sodium and beta 2- microglobulin increases progressively during the second half of gestation.


The following articles in journals at HighWire Press have cited this article:


Home page
 Am. J. Physiol. Renal Physiol.Home page
D. Edouga, B. Hugueny, B. Gasser, L. Bussieres, and K. Laborde
Recovery after relief of fetal urinary obstruction: morphological, functional and molecular aspects
Am J Physiol Renal Physiol, July 1, 2001; 281(1): F26 - F37.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
F. Muller, M.-A. Bernard, A. Benkirane, S. Ngo, S. Lortat-Jacob, J.-F. Oury, and M. Dommergues
Fetal Urine Cystatin C as a Predictor of Postnatal Renal Function in Bilateral Uropathies
Clin. Chem., December 1, 1999; 45(12): 2292 - 2293.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1996 by the American Association for Clinical Chemistry.