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Clinical Chemistry 42: 356-360, 1996;
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Clinical Chemistry, Vol 42, 356-360, Copyright © 1996 by American Association for Clinical Chemistry

Heteroduplex generator in analysis of Rh blood group alleles

J Stoerker, C Hurwitz, NC Rose, LE Silberstein and WE Highsmith
Avitech Diagnostics, Inc., Malvern, PA 19355, USA.

We describe the use of heteroduplex analysis to enhance the resolution of different rhesus-derived (Rh) isotypes. Heteroduplex analysis of different domains of the Rh D and Rh CE loci can be performed to diagnose a variety of blood group incompatibilities. One application of this technique is the ability to test for fetal-maternal blood group incompatibilities during pregnancy. Several new serotype-specific sequence variations were discovered in the mapping of the Rh locus, and used in the construction of artificial heteroduplex generators (HGs). HGs facilitate the resolution of the Rh isotypes by electrophoretic methods.


The following articles in journals at HighWire Press have cited this article:


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 Proc. Natl. Acad. Sci. USAHome page
W. Resch, N. Parkin, E. L. Stuelke, T. Watkins, and R. Swanstrom
A multiple-site-specific heteroduplex tracking assay as a tool for the study of viral population dynamics
PNAS, December 14, 2000; (2000) 11511298.
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N. D. Avent and M. E. Reid
The Rh blood group system: a review
Blood, January 15, 2000; 95(2): 375 - 387.
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Home page
 Proc. Natl. Acad. Sci. USAHome page
W. Resch, N. Parkin, E. L. Stuelke, T. Watkins, and R. Swanstrom
A multiple-site-specific heteroduplex tracking assay as a tool for the study of viral population dynamics
PNAS, January 2, 2001; 98(1): 176 - 181.
[Abstract] [Full Text] [PDF]


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Copyright © 1996 by the American Association for Clinical Chemistry.