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Clinical Chemistry 42: 618-624, 1996;
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Clinical Chemistry, Vol 42, 618-624, Copyright © 1996 by American Association for Clinical Chemistry

Laboratory testing for recent alcohol consumption: comparison of ethanol, methanol, and 5-hydroxytryptophol

A Helander, O Beck and AW Jones
Karolinska Institute, Department of Clinical Neuroscience, Psychiatry Section at St. Gorans Hospital, Stockholm, Sweden.

The ratio of 5-hydroxytryptophol to 5-hydroxyindole-3-acetic acid (5HTOL/5HIAA) in urine was compared with concentrations of ethanol and methanol as a way to monitor recent alcohol consumption. During detoxification of alcohol-dependent subjects, ethanol persisted longer in urine than in breath or plasma. Blood and urinary methanol remained increased for 2-6 h after blood ethanol had returned to background concentrations, whereas 5HTOL/5HIAA remained increased for 6-15 h. In healthy volunteers who had ingested alcohol (range 3-98 g) the previous afternoon or evening, 87% (for men) and 59% (for women) of all drinking occasions exceeding 7 g of alcohol were identified by an increased 5HTOL/5HIAA in the first morning urine void. This compared with 32% and 12%, respectively, identified by analysis of ethanol (>200 micromol/L). No gender difference in the excretion pattern of 5HTOL/5HIAA was seen. The results demonstrate that 5HTOL/5HIAA provides a specific and more sensitive method to detect recent alcohol consumption than does ethanol or methanol.


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G. Hoiseth, J. P. Bernard, N. Stephanson, P. T. Normann, A. S. Christophersen, J. Morland, and A. Helander
Comparison between the urinary alcohol markers EtG, EtS, and GTOL/5-HIAA in a controlled drinking experiment
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A. Helander, I. Olsson, and H. Dahl
Postcollection Synthesis of Ethyl Glucuronide by Bacteria in Urine May Cause False Identification of Alcohol Consumption
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O. Beck, N. Stephanson, M. Bottcher, N. Dahmen, C. Fehr, and A. Helander
Biomarkers to disclose recent intake of alcohol: potential of 5-hydroxytryptophol glucuronide testing using new direct UPLC-tandem MS and ELISA methods
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A. BISAGA, M. LAPOSATA, S. XIE, and S. M. EVANS
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B. Lumbreras-Lacarra, J. M. Ramos-Rincon, and I. Hernandez-Aguado
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T. Sarkola, H. Dahl, C. J. P. Eriksson, and A. Helander
URINARY ETHYL GLUCURONIDE AND 5-HYDROXYTRYPTOPHOL LEVELS DURING REPEATED ETHANOL INGESTION IN HEALTHY HUMAN SUBJECTS
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M. A. Refaai, P. N. Nguyen, T. S. Steffensen, R. J. Evans, J. E. Cluette-Brown, and M. Laposata
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M. Laposata
Fatty acid ethyl esters: short-term and long-term serum markers of ethanol intake
Clin. Chem., August 1, 1997; 43(8): 1527 - 1534.
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