| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Clinical Chemistry, Vol 42, 630-636, Copyright © 1996 by American Association for Clinical Chemistry
K Rasmussen, J Moller, M Lyngbak, AM Pedersen and L Dybkjaer
Department of Clinical Biochemistry, Aarhus University Hospital at Skejby, Denmark.
We present reference intervals for total homocysteine and methylmalonic acid in plasma based on samples from 126 women (ages 20-85 years, median 49 years) and 109 men (ages 20-84 years, median 50 years). The central 0.95 interval for methylmalonic acid was 0.08-0.28 micromol/L. Supplementation with cyanocobalamin caused a nonsignificant decrease in methylmalonic acid. Supplementation with folic acid caused a decrease in homocysteine concentrations, with data analysis identifying two significantly different clusters: 182 subjects with the lowest initial concentrations (7.76 +/- 1.54 micromol/L, mean +/- SD) and the smallest decrease (1.26 +/- 0.96 micromol/L), and 53 subjects with the highest initial concentrations (12.33 +/- 2.04 micromol/L) and greatest decrease (4.14 +/- 1.32 micromol/L). We argue in favor of the age- and gender-specific central 0.95 intervals obtained for the 182 subjects before being supplemented with folic acid: 4.6-8.1 micromol/L for subjects at <30 years; 4.5-7.9 micromol/L for women, ages 30-59 years; 6.3-11.2 micromol/L for men, ages 30-59 years; and 5.8-11.9 micromol/L for subjects at >60 years.
The following articles in journals at HighWire Press have cited this article:
|
|
 |
|
  K. M von Castel-Roberts, A. L. Morkbak, E. Nexo, C. A Edgemon, D. R Maneval, J. J Shuster, J. F Valentine, G. P. Kauwell, and L. B Bailey Holo-transcobalamin is an indicator of vitamin B-12 absorption in healthy adults with adequate vitamin B-12 status Am. J. Clinical Nutrition, April 1, 2007; 85(4): 1057 - 1061. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. L. Morkbak, A.-M. Hvas, Z. Lloyd-Wright, T. A.B. Sanders, O. Bleie, H. Refsum, O. K. Nygaard, and E. Nexo Effect of Vitamin B12 Treatment on Haptocorrin Clin. Chem., June 1, 2006; 52(6): 1104 - 1111. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. V. Bor, E. Lydeking-Olsen, J. Moller, and E. Nexo A daily intake of approximately 6 {micro}g vitamin B-12 appears to saturate all the vitamin B-12-related variables in Danish postmenopausal women Am. J. Clinical Nutrition, January 1, 2006; 83(1): 52 - 58. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Rej Clinical Chemistry through Clinical Chemistry: A Journal Timeline Clin. Chem., December 1, 2004; 50(12): 2415 - 2458. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Luchsinger, M. -X. Tang, S. Shea, J. Miller, R. Green, and R. Mayeux Plasma homocysteine levels and risk of Alzheimer disease Neurology, June 8, 2004; 62(11): 1972 - 1976. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Refsum, A. D. Smith, P. M. Ueland, E. Nexo, R. Clarke, J. McPartlin, C. Johnston, F. Engbaek, J. Schneede, C. McPartlin, et al. Facts and Recommendations about Total Homocysteine Determinations: An Expert Opinion Clin. Chem., January 1, 2004; 50(1): 3 - 32. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Lloyd-Wright, A.-M. Hvas, J. Moller, T. A.B. Sanders, and E. Nexo Holotranscobalamin as an Indicator of Dietary Vitamin B12 Deficiency Clin. Chem., December 1, 2003; 49(12): 2076 - 2078. [Full Text] [PDF]
|
|
|
|
|
|
S. Loikas, M. Lopponen, P. Suominen, J. Moller, K. Irjala, R. Isoaho, S.-L. Kivela, P. Koskinen, and T.-T. Pelliniemi RIA for Serum Holo-Transcobalamin: Method Evaluation in the Clinical Laboratory and Reference Interval Clin. Chem., March 1, 2003; 49(3): 455 - 462. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Johnson, N. A Hawthorne, W. R Brackett, J. G Fischer, E. W Gunter, R. H Allen, and S. P Stabler Hyperhomocysteinemia and vitamin B-12 deficiency in elderly using Title IIIc nutrition services Am. J. Clinical Nutrition, January 1, 2003; 77(1): 211 - 220. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Seshadri, A. Beiser, J. Selhub, P. F. Jacques, I. H. Rosenberg, R. B. D'Agostino, P. W.F. Wilson, and P. A. Wolf Plasma Homocysteine as a Risk Factor for Dementia and Alzheimer's Disease N. Engl. J. Med., February 14, 2002; 346(7): 476 - 483. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Tice, E. Ross, P. G. Coxson, I. Rosenberg, M. C. Weinstein, M. G. M. Hunink, P. A. Goldman, L. Williams, and L. Goldman Cost-effectiveness of Vitamin Therapy to Lower Plasma Homocysteine Levels for the Prevention of Coronary Heart Disease: Effect of Grain Fortification and Beyond JAMA, August 22, 2001; 286(8): 936 - 943. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.-M. Hvas, J. Ellegaard, and E. Nexo Vitamin B12 Treatment Normalizes Metabolic Markers But Has Limited Clinical Effect: A Randomized Placebo-controlled Study Clin. Chem., August 1, 2001; 47(8): 1396 - 1404. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A.-M. Hvas, J. Ellegaard, and E. Nexo Increased Plasma Methylmalonic Acid Level Does Not Predict Clinical Manifestations of Vitamin B12 Deficiency Arch Intern Med, June 25, 2001; 161(12): 1534 - 1541. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Fokkema, J. M. Weijer, D.A. J. Dijck-Brouwer, J. J. van Doormaal, and F. A.J. Muskiet Influence of Vitamin-optimized Plasma Homocysteine Cutoff Values on the Prevalence of Hyperhomocysteinemia in Healthy Adults Clin. Chem., June 1, 2001; 47(6): 1001 - 1007. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. B Rasmussen, L. Ovesen, I. Bulow, N. Knudsen, P. Laurberg, and H. Perrild Folate intake, lifestyle factors, and homocysteine concentrations in younger and older women Am. J. Clinical Nutrition, November 1, 2000; 72(5): 1156 - 1163. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Gaustadnes, N. Rudiger, K. Rasmussen, and J. Ingerslev Familial Thrombophilia Associated With Homozygosity for the Cystathionine {beta}-Synthase 833T->C Mutation Arterioscler Thromb Vasc Biol, May 1, 2000; 20(5): 1392 - 1395. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. H. Yu, R. Joubran, M. Asmi, T. Law, A. Spencer, M. Jouma, and N. Rifai Agreement among Four Homocysteine Assays and Results in Patients with Coronary Atherosclerosis and Controls Clin. Chem., February 1, 2000; 46(2): 258 - 264. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Pfeiffer, S. J. Smith, D. T. Miller, and E. W. Gunter Comparison of Serum and Plasma Methylmalonic Acid Measurements in 13 Laboratories: An International Study Clin. Chem., December 1, 1999; 45(12): 2236 - 2242. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Carmel, R. Green, D. W Jacobsen, K. Rasmussen, M. Florea, and C. Azen Serum cobalamin, homocysteine, and methylmalonic acid concentrations in a multiethnic elderly population: ethnic and sex differences in cobalamin and metabolite abnormalities Am. J. Clinical Nutrition, November 1, 1999; 70(5): 904 - 910. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Rasmussen, J. Moller, and M. Lyngbak Within-Person Variation of Plasma Homocysteine and Effects of Posture and Tourniquet Application Clin. Chem., October 1, 1999; 45(10): 1850 - 1855. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Selhub, P. F. Jacques, I. H. Rosenberg, G. Rogers, B. A. Bowman, E. W. Gunter, J. D. Wright, and C. L. Johnson Serum Total Homocysteine Concentrations in the Third National Health and Nutrition Examination Survey (1991-1994): Population Reference Ranges and Contribution of Vitamin Status to High Serum Concentrations Ann Intern Med, September 7, 1999; 131(5): 331 - 339. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Moller, K. Rasmussen, and L. Christensen External Quality Assessment of Methylmalonic Acid and Total Homocysteine Clin. Chem., September 1, 1999; 45(9): 1536 - 1542. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Causse, N. Siri, H. Bellet, S. Champagne, C. Bayle, P. Valdiguie, R. Salvayre, and F. Couderc Plasma Homocysteine Determined by Capillary Electrophoresis with Laser-induced Fluorescence Detection Clin. Chem., March 1, 1999; 45(3): 412 - 414. [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Stern, J. L. Saver, R. M. Boldy, and F. DeGregorio Homocysteine Associated Hypercoagulability and Disseminated Thrombosis: A Case Report Angiology, October 1, 1998; 49(10): 765 - 769. [Abstract] [PDF]
|
|
|
|
|
|
M. P. Hughes, T. H. Carlson, M. K. McLaughlin, and D. D. Bankson Addition of Sodium Fluoride to Whole Blood Does Not Stabilize Plasma Homocysteine But Produces Dilution Effects on Plasma Constituents and Hematocrit Clin. Chem., October 1, 1998; 44(10): 2204 - 2206. [Full Text] [PDF]
|
|
|
|
|
|
D. A. J. Brouwer, H. T. M. E. Welten, D.-J. Reijngoud, J. J. van Doormaal, and F. A. J. Muskiet Plasma folic acid cutoff value, derived from its relationship with homocyst(e)ine Clin. Chem., July 1, 1998; 44(7): 1545 - 1550. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Probst, R. Brandl, M. Blumke, and D. Neumeier Stabilization of Homocysteine Concentration in Whole Blood Clin. Chem., July 1, 1998; 44(7): 1567 - 1569. [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. Jacob, D. M. Gretz, P. C. Taylor, S. J. James, I. P. Pogribny, B. J. Miller, S. M. Henning, and M. E. Swendseid Moderate Folate Depletion Increases Plasma Homocysteine and Decreases Lymphocyte DNA Methylation in Postmenopausal Women J. Nutr., July 1, 1998; 128(7): 1204 - 1212. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. K. Hoogeveen, P. J. Kostense, P. J. Beks, A. J. C. Mackaay, C. Jakobs, L. M. Bouter, R. J. Heine, and C. D. A. Stehouwer Hyperhomocysteinemia Is Associated With an Increased Risk of Cardiovascular Disease, Especially in Non–Insulin-Dependent Diabetes Mellitus : A Population-Based Study Arterioscler Thromb Vasc Biol, January 1, 1998; 18(1): 133 - 138. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Clarke, P. Woodhouse, A. Ulvik, C. Frost, P. Sherliker, H. Refsum, P. M. Ueland, and K.-T. Khaw Variability and determinants of total homocysteine concentrations in plasma in an elderly population Clin. Chem., January 1, 1998; 44(1): 102 - 107. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. H. Moghadasian, B. M. McManus, and J. J. Frohlich Homocyst(e)ine and Coronary Artery Disease: Clinical Evidence and Genetic and Metabolic Background Arch Intern Med, November 10, 1997; 157(20): 2299 - 2308. [Abstract] [PDF]
|
|
|
|
|
|
M. A. Vilaseca, D. Moyano, I. Ferrer, and R. Artuch Total Homocysteine in Pediatric Patients Clin. Chem., April 1, 1997; 43(4): 690 - 692. [Full Text]
|
|
|
|
 |
|
 S. Sengupta, H. Chen, T. Togawa, P. M. DiBello, A. K. Majors, B. Budy, M. E. Ketterer, and D. W. Jacobsen Albumin Thiolate Anion Is an Intermediate in the Formation of Albumin-S-S-Homocysteine J. Biol. Chem., August 3, 2001; 276(32): 30111 - 30117. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
