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Clinical Chemistry 42: 691-695, 1996;
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Clinical Chemistry, Vol 42, 691-695, Copyright © 1996 by American Association for Clinical Chemistry

Physical activity releases prostate-specific antigen (PSA) from the prostate gland into blood and increases serum PSA concentrations

GM Oremek and UB Seiffert
Clinical Chemistry Laboratories, Klinikum der Goethe-Universitat, Frankfurt am Main, Germany.

Determination of prostate-specific antigen (PSA) is an established tool in detecting prostate cancer. However, the effect of physical activity on the PSA concentration in serum is controversial. We measured serum concentrations of PSA and prostatic acid phosphatase (PAP) in 301 healthy outpatients before and after they performed standardized exercise. Immediately after 15 min of exercise on a bicycle ergometer, their serum PSA concentrations increased by as much as threefold. The increase was age dependent and correlated to the PSA concentration before exercise. This increase was evident in both the free and complexed fractions of PSA. The amount of PSA secreted into blood depends on the volume of the prostate, whereas productivity of the prostate epithelium remains constant or increases slightly with age. We present cutoff values for clinical use. PAP was also increased, but to a lesser extent. The PSA and PAP secretion mechanisms differ. Our data suggest that extensive physical activity should be avoided before blood sampling for diagnostic purposes and, in case of an increase, the PSA concentration should be controlled after an exercise test.


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T. Piironen, M. Nurmi, K. Irjala, O. Heinonen, H. Lilja, T. Lovgren, and K. Pettersson
Measurement of Circulating Forms of Prostate-specific Antigen in Whole Blood Immediately after Venipuncture: Implications for Point-of-Care Testing
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M. Crook, K. Preston, and I. Lancaster
Serum Prostatic Specific-Antigen Concentrations in Acute Myocardial Infarction
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G. Banfi, M. Pontillo, A. Dolci, and G. S. Roi
Prostate-Specific Antigen is Not Increased in Young Men by Ultraendurance Sport Performances
Clin. Chem., August 1, 1997; 43(8): 1465 - 1466.
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