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Clinical Chemistry 42: 933-941, 1996;
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Clinical Chemistry, Vol 42, 933-941, Copyright © 1996 by American Association for Clinical Chemistry

Clinical comparison of three labeled-antibody immunoassays of free triiodothyronine

ML Piketty, M d'Herbomez, D Le Guillouzic, R Lebtahi, E Cosson, A Dumont, A Dilouya and BO Helal
Laboratoire RIA, CH Sainte Anne, Paris, France.

Three labeled-antibody immunoassays of free triiodothyronine (FT3) were studied in hyperthyroid patients, patients with nonthyroidal illness, and patients being treated with amiodarone; we also studied sera presenting known interferences (n for all groups = 465). The results were compared with those of a one-step labeled-analog assay. The precision of the two automated assays were similar to that of the manual assays. The three labeled-antibody FT3 assays demonstrated a satisfactory diagnostic performance for confirming hyperthyroidism and robustness to interference; nevertheless, two assays displayed unusual behavior in some patients with nonthyroidal illness, with chronic renal failure, or after amiodarone therapy.


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Home page
 Clin. Chem.Home page
P. Verheecke
Free triiodothyronine concentration in serum of 1050 euthyroid children is inversely related to their age
Clin. Chem., June 1, 1997; 43(6): 963 - 967.
[Abstract] [Full Text] [PDF]


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