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Clinical Chemistry 42: 970-972, 1996;
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Clinical Chemistry, Vol 42, 970-972, Copyright © 1996 by American Association for Clinical Chemistry

Evolution of serum lipids in two male bodybuilders using anabolic steroids

F Lajarin, R Zaragoza, I Tovar and P Martinez-Hernandez
Servicio de Analisis Clinicos, Hospital Universitario Virgen de la Arrixaca, Crta. de Madrid s/n, El Palmar, Murcia, Spain.

We followed weekly the evolution of serum lipid concentrations in two bodybuilders undergoing a cycle of treatment with anabolic steroids. These drugs caused maximum depression of high-density lipoprotein cholesterol concentrations by 69.1% in the fifth week after the beginning of the cycle for subject 1, and by 72.4% in the fourth week for subject 2. Maximum increases in low-density lipoprotein cholesterol concentrations were 144% and 156%, respectively. Total cholesterol and apolipoprotein (apo) B were highly increased with anabolic steroid use. We also saw depression of apo A-I by 84% and 91%, and lipoprotein(a) decreased to undetectable amounts in both cases. These effects were reversed 10 weeks after the end of the steroid cycle in subject 1, but subject 2 still presented abnormal concentrations of serum lipids 13 weeks after drug cessation. The periods until reversibility of anabolic steroid effects on lipids were longer than those reported in previous studies.




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Copyright © 1996 by the American Association for Clinical Chemistry.